ArticleScientific reports2018
Mapping the Transport Kinetics of Molecules and Particles in Idealized Intracranial Side Aneurysms.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 20 citations in OpenAlex.
- From barrier to guide: Exploiting disease-specific hemodynamics for enhanced nanodrug targeting in cardiovascular diseases.Pharmaceutical science advances · 2026Review
- Hemodynamic characteristics and drug deposition in cerebral aneurysm sac.Scientific reports · 2025Article
- Biomimetic Glycosaminoglycan-Analog Hydrogel for Improved Embolization of Aneurysms: Environment-Selective Swelling.Advanced healthcare materials · 2025Article
- Development of an in-vitro model based on patient vessel geometry for simulated use testing in neurointerventional surgery.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2025Article
- Fluid dynamics in intracranial aneurysms treated with flow-diverting stents: effect of multiple geometrical parameters.Journal of fluid mechanics · 2023Article
- Influence of Blood Rheology and Turbulence Models in the Numerical Simulation of Aneurysms.Bioengineering (Basel, Switzerland) · 2023Article
- Transcriptomic analysis of a 3D blood-brain barrier model exposed to disturbed fluid flow.Fluids and barriers of the CNS · 2022Article
- Biophysical targeting of high-risk cerebral aneurysms.Bioengineering & translational medicine · 2022Article
- The effect of Dean, Reynolds, and Womersley number on the flow in a spherical cavity on a curved round pipe. Part 1. Fluid mechanics in the cavity as a canonical flow representing intracranial aneurysms.Journal of fluid mechanics · 2021Article
- Computational and experimental investigation of particulate matter deposition in cerebral side aneurysms.Journal of the Royal Society, Interface · 2020Article
- Impact of Intracranial Aneurysm Morphology and Rupture Status on the Particle Residence Time.Journal of neuroimaging : official journal of the American Society of Neuroimaging · 2019Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Intracranial side aneurysms (IA) are pathological blood-filled bulges in cerebral blood vessels. Unlike healthy blood vessels where mass transport is dominated by convection, both diffusion and convection can play an active role in aneurysm sites. Here, we study via dye washout experiments and numerical simulations, the transport characteristics of particles (1 micron) and small molecules (300 Da) into simplified side aneurysms models following bolus injection. Time-lapse fluorescent microscopy imaging performed in our idealized aneurysm models showed that the parent artery geometry (located on the inner vs. outer curvature) as well as the aneurysm aspect ratio (AR) affect the washout kinetics while the pulsatile nature of the flow, maintained within the physiological range, carries only a minor effect. Importantly, in the absence of effective diffusion, particles that are located on slow streamlines linger within the aneurysm cavity, a phenomenon that could be of importance in deposition of cells and nano/micro-particles within aneurysms. Altogether, mass transport studies may provide valuable insights for better understanding of aneurysm pathophysiology as well as for the design of new diagnostic and theranostic nano-medicines.
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