Evidence map›Paper›PMID 29867109›Full record

Trial reportTranslational psychiatry2018

A longitudinal study on deep brain stimulation of the medial forebrain bundle for treatment-resistant depression.

Albert J Fenoy, Paul E Schulz, Sudhakar Selvaraj, Christina L Burrows, Giovanna Zunta-Soares, Kathryn Durkin, Paolo Zanotti-Fregonara, Joao Quevedo, Jair C Soares

Registry-linked trialAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Translational psychiatry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06096207 (Deep Brain Stimulation), which is not on this map. Cited by 59 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06096207 phase1recruitingnot on this mapstarted 2023, after this paper: background citation

Deep Brain Stimulation (DBS) Therapy for Treatment Resistant Depression

TypeinterventionalSponsorNorthwell HealthRan2023 to 2038Enrolled20ConditionsTreatment Resistant DepressionArmsMedtronic SenSight Directional DBS lead
3 · Its place in the literature

Who cites it

59 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Superolateral medial forebrain bundle deep brain stimulation in major depression: a gateway trial.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019
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  14. A review of diffusion MRI in mood disorders: mechanisms and predictors of treatment response.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Albert J FenoyDepartment of Neurosurgery, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA. albert.j.fenoy@uth.tmc.edu.
Paul E SchulzDepartment of Neurology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA.
Sudhakar SelvarajCenter of Excellence on Mood Disorders, Department of Psychiatry and Behavioral Sciences, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA.
Christina L BurrowsDepartment of Neurology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA.
Giovanna Zunta-SoaresCenter of Excellence on Mood Disorders, Department of Psychiatry and Behavioral Sciences, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA.
Kathryn DurkinCenter of Excellence on Mood Disorders, Department of Psychiatry and Behavioral Sciences, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA.
Paolo Zanotti-FregonaraDepartment of Neurology, Houston Methodist Research Institute and Weill Cornell Medicine, Houston, TX, USA.
Joao QuevedoCenter of Excellence on Mood Disorders, Department of Psychiatry and Behavioral Sciences, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA.
Jair C SoaresCenter of Excellence on Mood Disorders, Department of Psychiatry and Behavioral Sciences, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA.

Funding

Center for Clinical and Translational Sciences (CCTS)UL1TR000371 · NCATS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI MCPHERSON, DAVID D · 2012 to 2016
$13.4M
NCATS NIH HHS UL1 TR000371
6 · The paper itself

Abstract

Deep brain stimulation (DBS) to the superolateral branch of the medial forebrain bundle (MFB) has been reported to lead to rapid antidepressant effects. In this longitudinal study, we expand upon the initial results we reported at 26 weeks (Fenoy et al., 2016), showing sustained antidepressant effects of MFB DBS on six patients with treatment-resistant depression (TRD) over 1 year. The Montgomery-Åsberg Depression Rating Scale (MADRS) was used as the primary assessment tool. Deterministic fiber tracking was used to individually map the target area; analysis was performed to compare modulated fiber tracts between patients. Intraoperatively, upon stimulation at target, responders reported immediate increases in energy and motivation. An insertional effect was seen during the 4-week sham stimulation phase from baseline (28% mean MADRS reduction, p = 0.02). However, after 1 week of initiating stimulation, three of six patients had a > 50% decrease in MADRS scores relative to baseline (43% mean MADRS reduction, p = 0.005). One patient withdrew from study participation. At 52 weeks, four of remaining five patients have > 70% decrease in MADRS scores relative to baseline (73% mean MADRS reduction, p = 0.007). Evaluation of modulated fiber tracts reveals significant common orbitofrontal connectivity to the target region in all responders. Neuropsychological testing and

Indexed as

Deep Brain StimulationAdultDepressive Disorder, Treatment-ResistantFemaleHumansLongitudinal StudiesMaleMedial Forebrain BundleMiddle AgedMotivationNeuropsychological TestsPositron-Emission TomographyPsychiatric Status Rating ScalesTexasTreatment OutcomeYoung Adult

Identifiers

PMID29867109
PMCPMC5986795

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.