ArticleCell death & disease2018
Metabolic patterns in insulin-resistant male hypogonadism.
Article in Cell death & disease, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- The male-to-female ratio in late-onset multiple acyl-CoA dehydrogenase deficiency: a systematic review and meta-analysis.Orphanet journal of rare diseases · 2024Pooled it
- Testosterone plus lifestyle therapy improves skeletal muscle glycolysis in older men with obesity and hypogonadism.Frontiers in endocrinology · 2025Trial
- A Novel HemizygousCase reports in endocrinology · 2026Article
- Article
- The role of triglyceride-glucose index in the differential diagnosis of atherosclerotic stroke and cardiogenic stroke.BMC cardiovascular disorders · 2024Article
- Acquired Male Hypogonadism in the Post-Genomic Era-A Narrative Review.Life (Basel, Switzerland) · 2023Review
- Skeletal muscle analysis of cancer patients reveals a potential role for carnosine in muscle wasting.Journal of cachexia, sarcopenia and muscle · 2023Article
- Biomarkers to Be Used for Decision of Treatment of Hypogonadal Men with or without Insulin Resistance.Metabolites · 2023Review
- Plasma metabolomics in male primary and functional hypogonadism.Frontiers in endocrinology · 2023Review
- The sex life of male patients with cirrhosis and its organic factors: What we have got so far?PloS one · 2023Observational
- On the Need to Distinguish between Insulin-Normal and Insulin-Resistant Patients in Testosterone Therapy.International journal of molecular sciences · 2022Review
- Plasma metabolome study reveals metabolic changes induced by pharmacological castration and testosterone supplementation in healthy young men.Scientific reports · 2022Article
- Plasma Metabonomics in Insulin-Resistant Hypogonadic Patients Induced by Testosterone Treatment.International journal of molecular sciences · 2022Article
- Plasma Metabolomics Profile of "Insulin Sensitive" Male Hypogonadism after Testosterone Replacement Therapy.International journal of molecular sciences · 2022Article
- Intergenerational effects of preconception opioids on glucose homeostasis and hepatic transcription in adult male rats.Scientific reports · 2022Article
- The Microbiota and It's Correlation With Metabolites in the Gut of Mice With Nonalcoholic Fatty Liver Disease.Frontiers in cellular and infection microbiology · 2022Article
- Inverse association between serum bilirubin level and testosterone deficiency in middle-aged and older men.Scientific reports · 2021Article
- Joint effect of diabetes and opiate use on all-cause and cause-specific mortality: the Golestan cohort study.International journal of epidemiology · 2021Article
- Association Between Low Serum Testosterone and the Development of Metabolic Syndrome in Elderly Taiwanese Men.Diabetes, metabolic syndrome and obesity : targets and therapy · 2021Article
- Metabolic regulation of kisspeptin - the link between energy balance and reproduction.Nature reviews. Endocrinology · 2020Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Male hypogonadism associated with insulin resistance (IR) very often leads to metabolic syndrome, at variance with hypogonadism in its first stadium of insulin sensitivity (IS). A plasma metabolomic investigation of these patients can provide useful information in comparison with the values of IS patients. To this aim plasma from insulin-resistant males with hypogonadism were analysed by using ultra high-performance liquid chromatography (UHPLC) and high-resolution mass spectrometry (HRMS). Thus, metabolites were compared to the controls through multivariate statistical analysis and grouped by metabolic pathways. Metabolite database searches and pathway analyses identified imbalances in 18-20 metabolic pathways. Glucose metabolism (e.g., glycolysis and the Krebs cycle) is fuelled by amino acids degradation, in particular of branched amino acids, in individuals with lean body mass. Gluconeogenesis is strongly activated. Some crucial pathways such as glycerol are skewed. Mitochondrial electron transport is affected with a reduction in ATP production. Beta-oxidation of short and medium chain fatty acids did not represent an energy source in hypogonadism, at variance with long and branched fatty acids, justifying the increase in fat mass. Carnosine and β-alanine are strongly reduced resulting in increased fatigue and mental confusion. A comparison of IR with IS male hypogonadism will contribute to a better understanding of how these two hormones work in synergy or antagonise each other in humans. It could also help to select patients who will respond to hormone treatment, and provide accurate biomarkers to measure the response to treatment eventually leading to better strategies in preventing systemic complications in patients not fit for hormone replacement therapy.
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Registered trials
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