Evidence map›Paper›PMID 29866910›Full record

ArticleInfection and immunity2018

Methylthioadenosine Suppresses Salmonella Virulence.

Jeffrey S Bourgeois, Daoguo Zhou, Teresa L M Thurston, James J Gilchrist, Dennis C Ko

Open access · hybridAbstract read
In one paragraph

Article in Infection and immunity, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.0field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Integration of themBio · 2022
    Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Frontiers in cellular and infection microbiology · 2019
    Review
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 2 countries.

Jeffrey S BourgeoisDepartment of Molecular Genetics and Microbiology, School of Medicine, Duke University, Durham, North Carolina, USA.
Daoguo ZhouDepartment of Biological Sciences, Purdue University, West Lafayette, Indiana, USA.
Teresa L M ThurstonSection of Microbiology, Centre for Molecular Microbiology and Infection, Imperial College London, London, United Kingdom.
James J Gilchrist *Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom james.gilchrist@paediatrics.ox.ac.uk dennis.ko@duke.edu.
Dennis C Ko *Department of Molecular Genetics and Microbiology, School of Medicine, Duke University, Durham, North Carolina, USA james.gilchrist@paediatrics.ox.ac.uk dennis.ko@duke.edu.ORCID https://orcid.org/0000-0002-0113-5981
Duke University · USCentre for Human Genetics · GBImperial College London · GBPurdue University West Lafayette · US

Funding

Genetics Training Grant-Year 26T32GM007754 · NIGMS · DUKE UNIVERSITY · PI HAASE, STEVEN B · 1985 to 2019
$8.3M
HUMAN GENETIC VARIATION REGULATING SALMONELLA HOST-PATHOGEN INTERACTIONS AND DISEASE SUSCEPTIBILITYR01AI118903 · NIAID · DUKE UNIVERSITY · PI KO, DENNIS CHUN-YONE · 2015 to 2024
$4.2M
Data commons for 'omic, microscopy and analysis core facilitiesS10OD018164 · OD · DUKE UNIVERSITY · PI WRAY, GREGORY A. · 2014 to 2014
$598k
Medical Research Council MR/P028225/1NIAID NIH HHS R01 AI118903NIGMS NIH HHS T32 GM007754NIH HHS S10 OD018164Wellcome Trust 102342/Z/13/Z
6 · The paper itself

Abstract

In order to deploy virulence factors at appropriate times and locations, microbes must rapidly sense and respond to various metabolite signals. Previously, we showed a transient elevation of the methionine-derived metabolite methylthioadenosine (MTA) concentration in serum during systemic

Indexed as

AdenosineAnimalsBacterial ProteinsDisease Models, AnimalFlagellaGene Expression Regulation, BacterialGenomic IslandsMethionineMiceMice, Inbred C57BLPolyaminesRepressor ProteinsSalmonella Infections, AnimalSalmonella typhimuriumVirulenceVirulence FactorsAdenosineBacterial ProteinsMethioninemethionine repressor protein, BacteriaPolyaminesRepressor ProteinsVirulence Factorsflagellar motilityinflammationmetabolismmethionine salvagemethylthioadenosinemetJSalmonellaSPI-1virulence regulation

Identifiers

PMID29866910
PMCPMC6105896
OpenAlexW2805341145

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.