Evidence map›Paper›PMID 29866907›Full record

ArticleInfection and immunity2018

Enzymatic Hydrolysis of Pneumococcal Capsular Polysaccharide Renders the Bacterium Vulnerable to Host Defense.

Dustin R Middleton, Amy V Paschall, Jeremy A Duke, Fikri Y Avci

Open access · bronzeAbstract read
In one paragraph

Article in Infection and immunity, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 25 citations in OpenAlex.

  1. Review
  2. Article
  3. Infection and immunity · 2022
    Article
  4. Review
  5. Article
  6. MgaVirulence · 2021
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Panel 1: Biotechnology, biomedical engineering and new models of otitis media.International journal of pediatric otorhinolaryngology · 2020
    Review
  12. Identification ofFrontiers in microbiology · 2020
    Article
  13. Review
  14. Article
  15. Article
  16. Blood‒Brain Barrier Pathology and CNS Outcomes inInternational journal of molecular sciences · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Dustin R MiddletonDepartment of Biochemistry and Molecular Biology, Center for Molecular Medicine and Complex Carbohydrate Research Center, University of Georgia, Athens, Georgia, USA.
Amy V PaschallDepartment of Biochemistry and Molecular Biology, Center for Molecular Medicine and Complex Carbohydrate Research Center, University of Georgia, Athens, Georgia, USA.
Jeremy A DukeDepartment of Biochemistry and Molecular Biology, Center for Molecular Medicine and Complex Carbohydrate Research Center, University of Georgia, Athens, Georgia, USA.
Fikri Y AvciDepartment of Biochemistry and Molecular Biology, Center for Molecular Medicine and Complex Carbohydrate Research Center, University of Georgia, Athens, Georgia, USA avci@uga.edu.
University of Georgia · US

Funding

Molecular Mechanisms for Carbohydrate Presentation to CD4+ T cells by MHCII PathwayR01AI123383 · NIAID · UNIVERSITY OF GEORGIA · PI Fikri Y Avci · 2016 to 2026
$4.2M
Glycoscience Training ProgramT32GM107004 · NIGMS · UNIVERSITY OF GEORGIA · PI AMSTER, I JONATHAN, HALTIWANGER, ROBERT S. · 2014 to 2021
$1.3M
Pn3Pase as an Effective Enzyme Therapeutic for Streptococcus Pneumoniae type 3 InfectionR41AI157287 · NIAID · PNEUMOTACTIX, LLC · PI AVCI, FIKRI Y · 2021 to 2022
$599k
NIAID NIH HHS R01 AI123383NIAID NIH HHS R41 AI157287NIGMS NIH HHS T32 GM107004
6 · The paper itself

Abstract

Despite a century of investigation,

Indexed as

AnimalsBacterial CapsulesGlycoside HydrolasesHost-Pathogen InteractionsHumansHydrolysisMicePhagocytosisPneumococcal InfectionsPolysaccharides, BacterialStreptococcus pneumoniaeGlycoside HydrolasesPolysaccharides, Bacterialcapsular polysaccharidecolonizationcomplementglycoside hydrolaseinvasive pneumococcal diseasesserotype 3Streptococcus pneumoniae

Identifiers

PMID29866907
PMCPMC6056847
OpenAlexW2805868597

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.