Evidence map›Paper›PMID 29866884›Full record

ArticleThe Journal of biological chemistry2018

DNA methylation regulates the neonatal CD4

Sharon A McGrath-Morrow, Roland Ndeh, Kathryn A Helmin, Shang-Yang Chen, Kishore R Anekalla, Hiam Abdala-Valencia, Franco R D'Alessio, J Michael Collaco, Benjamin D Singer

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 55 citations in OpenAlex.

  1. Trial
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  13. Science advances · 2023
    Article
  14. Review
  15. Article
  16. Article
  17. Advancing Lung Immunology Research: An Official American Thoracic Society Workshop Report.American journal of respiratory cell and molecular biology · 2022
    Article
  18. Article
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  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Sharon A McGrath-MorrowFrom the Eudowood Division of Pediatric Respiratory Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287.
Roland NdehFrom the Eudowood Division of Pediatric Respiratory Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287.
Kathryn A HelminDivision of Pulmonary and Critical Care Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611.
Shang-Yang ChenDivision of Pulmonary and Critical Care Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611.
Kishore R AnekallaDivision of Pulmonary and Critical Care Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611.
Hiam Abdala-ValenciaDivision of Pulmonary and Critical Care Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611.
Franco R D'AlessioDivision of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, and.
J Michael CollacoFrom the Eudowood Division of Pediatric Respiratory Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287.
Benjamin D SingerDivision of Pulmonary and Critical Care Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, benjamin-singer@northwestern.edu.ORCID 0000-0001-5775-8427
Northwestern University · USJohns Hopkins University · US

Funding

Translational Research Central ServicesP30CA006973 · NCI · JOHNS HOPKINS UNIVERSITY · PI Rosalie Wollett · 1985 to 2026
$208.6M
Technology CoreU19AI135964 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI ALAN R HAUSER · 2018 to 2026
$24.7M
Phenotype-Specific Immune Responses in the Systemic VasculitidesP30AR053503 · NIAMS · JOHNS HOPKINS UNIVERSITY · PI SOLOSKI, MARK J · 2006 to 2015
$6.4M
Resolution of Diffuse Inflammatory Lung Injury in Neonatal MiceR01HL114800 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI MCGRATH-MORROW, SHARON ANN · 2013 to 2021
$3.3M
Regulatory T cell Uhrf1 and DNA methylation in repair of acute lung injuryK08HL128867 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI SINGER, BENJAMIN DAVID · 2015 to 2019
$779k
NCI NIH HHS P30 CA006973NHLBI NIH HHS K08 HL128867NHLBI NIH HHS R01 HL114800NIAID NIH HHS U19 AI135964NIAMS NIH HHS P30 AR053503
6 · The paper itself

Abstract

Pediatric acute lung injury, usually because of pneumonia, has a mortality rate of more than 20% and an incidence that rivals that of all childhood cancers combined. CD4

Indexed as

DNA MethylationAnimalsAnimals, NewbornCD4-Positive T-LymphocytesCpG IslandsEpigenesis, GeneticEscherichia coliEscherichia coli InfectionsMiceMice, Inbred C57BLPneumoniaTranscriptional Activationacute lung injurybisulfite sequencingCD4+ T-cellscluster of differentiation 4 (CD4)developmentDNA methylationEscherichia coli (E. coli)gene transcriptionlung injuryneonatespneumoniaRNA-sequencingtranscription

Identifiers

PMID29866884
PMCPMC6066312
OpenAlexW2807216425

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.