ArticleThe Journal of biological chemistry2018
Intermolecular autocatalytic activation of serine protease zymogen factor C through an active transition state responding to lipopolysaccharide.
Article in The Journal of biological chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 17 citations in OpenAlex.
- Extravascular coagulation regulates haemostasis independently of activated platelet surfaces in an in vivo mouse model.Communications biology · 2025Article
- Genome Assembly of a Living Fossil, the Atlantic Horseshoe Crab Limulus polyphemus, Reveals Lineage-Specific Whole-Genome Duplications, Transposable Element-Based Centromeres, and a ZW Sex Chromosome System.Molecular biology and evolution · 2025Article
- Reconstitution of (1→3)-β-D-glucans measurement system using recombinant Limulus polyphemus Factor G.Applied microbiology and biotechnology · 2023Article
- Digestion-related proteins in the tobacco hornworm, Manduca sexta.Insect biochemistry and molecular biology · 2020Article
- Roles of the clip domains of two protease zymogens in the coagulation cascade in horseshoe crabs.The Journal of biological chemistry · 2020Article
- Immune Responses to Gram-Negative Bacteria in Hemolymph of the Chinese Horseshoe Crab,Frontiers in immunology · 2020Article
- A statistical model for activation of Factor C by binding to LPS aggregates.European biophysics journal : EBJ · 2019Article
- Detecting lipopolysaccharide in the cytosol of mammalian cells: Lessons from MD-2/TLR4.Journal of leukocyte biology · 2019Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Horseshoe crab hemolymph coagulation is believed to be triggered by the autocatalytic activation of serine protease zymogen factor C to the active form, α-factor C, belonging to the trypsin family, through an active transition state of factor C responding to bacterial lipopolysaccharide (LPS), designated factor C*. However, the existence of factor C* is only speculative, and its proteolytic activity has not been validated. In addition, it remains unclear whether the proteolytic cleavage of the Phe
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.