ArticleAntimicrobial agents and chemotherapy2018
Artemisone and Artemiside Are Potent Panreactive Antimalarial Agents That Also Synergize Redox Imbalance in Plasmodium falciparum Transmissible Gametocyte Stages.
Open access · bronzeAbstract read
In one paragraph
Article in Antimicrobial agents and chemotherapy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
4.8field-weighted citation impact, top 5% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 43 citations in OpenAlex.
- Computational Analysis of Plasmodium falciparum DNA Damage Inducible Protein 1 (PfDdi1): Insights into Binding of Artemisinin and its Derivatives and Implications for Antimalarial Drug Design.Cell biochemistry and biophysics · 2025Article
- The ATM Kinase Inhibitor AZD0156 Is a Potent Inhibitor of Plasmodium Phosphatidylinositol 4-Kinase (PI4Kβ) and Is an Attractive Candidate for Medicinal Chemistry Optimization Against Malaria.Angewandte Chemie (International ed. in English) · 2025Article
- The novel amino-artemisinin derivative WHN-11 disrupts mitochondria and protein homeostasis, and induces autophagy and apoptosis in cancer cells.Scientific reports · 2025Article
- Genetic complexity alters drug susceptibility of asexual and gametocyte stages ofAntimicrobial agents and chemotherapy · 2024Article
- Single and combination treatment of Toxoplasma gondii infections with a bumped kinase inhibitor and artemisone in vitro and with artemiside in experimentally infected mice.Experimental parasitology · 2023Article
- Efficacies and ADME properties of redox active methylene blue and phenoxazine analogues for use in new antimalarial triple drug combinations with amino-artemisinins.Frontiers in pharmacology · 2023Article
- New Transmission-Selective Antimalarial Agents through Hit-to-Lead Optimization of 2-([1,1'-Biphenyl]-4-carboxamido)benzoic Acid Derivatives.Chembiochem : a European journal of chemical biology · 2022Article
- Contemporary exploitation of natural products for arthropod-borne pathogen transmission-blocking interventions.Parasites & vectors · 2022Review
- In Vitro Activity of the Arylaminoartemisinin GC012 againstPathogens (Basel, Switzerland) · 2022Article
- Peroxide Antimalarial Drugs Target Redox Homeostasis inACS infectious diseases · 2022Article
- Streamlined and Robust Stage-Specific Profiling of Gametocytocidal Compounds AgainstFrontiers in cellular and infection microbiology · 2022Article
- Adapt or Die: Targeting Unique Transmission-Stage Biology for Malaria Elimination.Frontiers in cellular and infection microbiology · 2022Review
- The evaluation of ADME and pharmacokinetic properties of decoquinate derivatives for the treatment of malaria.Frontiers in pharmacology · 2022Article
- Antimalarial and antitumour activities of the steroidal quinone-methide celastrol and its combinations with artemiside, artemisone and methylene blue.Frontiers in pharmacology · 2022Article
- The Artemiside-Artemisox-Artemisone-M1 Tetrad: Efficacies against Blood StagePharmaceutics · 2021Article
- Intracellular Accumulation of Novel and Clinically Used TB Drugs Potentiates Intracellular Synergy.Microbiology spectrum · 2021Article
- Liposomes for malaria management: the evolution from 1980 to 2020.Malaria journal · 2021Review
- Toward New Transmission-Blocking Combination Therapies: Pharmacokinetics of 10-Amino-Artemisinins and 11-Aza-Artemisinin and Comparison with Dihydroartemisinin and Artemether.Antimicrobial agents and chemotherapy · 2021Article
- Synergistic Therapies as a Promising Option for the Treatment of Antibiotic-ResistantAntibiotics (Basel, Switzerland) · 2020Review
- Enhancing the antimalarial activity of artesunate.Parasitology research · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 5 institutions in 3 countries.
Dina CoertzenDepartment of Biochemistry, University of Pretoria Institute for Sustainable Malaria Control, University of Pretoria, Hatfield, South Africa.ORCID 0000-0002-8408-244X
Janette ReaderDepartment of Biochemistry, University of Pretoria Institute for Sustainable Malaria Control, University of Pretoria, Hatfield, South Africa.
Mariëtte van der WattDepartment of Biochemistry, University of Pretoria Institute for Sustainable Malaria Control, University of Pretoria, Hatfield, South Africa.
Sindisiwe H NondabaDepartment of Biochemistry, University of Pretoria Institute for Sustainable Malaria Control, University of Pretoria, Hatfield, South Africa.
Liezl GibhardDivision of Clinical Pharmacology, Department of Medicine, Groote Schuur Hospital, University of Cape Town, Observatory, South Africa.ORCID 0000-0003-0089-2136
Lubbe WiesnerDivision of Clinical Pharmacology, Department of Medicine, Groote Schuur Hospital, University of Cape Town, Observatory, South Africa.
Peter SmithDivision of Clinical Pharmacology, Department of Medicine, Groote Schuur Hospital, University of Cape Town, Observatory, South Africa.
Sarah D'AlessandroDipartimento di Scienze Farmacologiche e Biomolecolari (DiSFeB), Università degli Studi di Milano, Milan, Italy.
Donatella TaramelliDipartimento di Scienze Farmacologiche e Biomolecolari (DiSFeB), Università degli Studi di Milano, Milan, Italy.
Ho Ning WongCenter of Excellence for Pharmaceutical Sciences, Faculty of Health Sciences, North-West University, Potchefstroom, South Africa.
Jan L du PreezCenter of Excellence for Pharmaceutical Sciences, Faculty of Health Sciences, North-West University, Potchefstroom, South Africa.
Ronald Wai Keung WuDepartment of Chemistry, The Hong Kong University of Science and Technology, Kowloon, Hong Kong.
Lyn-Marie BirkholtzDepartment of Biochemistry, University of Pretoria Institute for Sustainable Malaria Control, University of Pretoria, Hatfield, South Africa lbirkholtz@up.ac.za richard.haynes@nwu.ac.za.ORCID 0000-0001-5888-2905
Richard K HaynesCenter of Excellence for Pharmaceutical Sciences, Faculty of Health Sciences, North-West University, Potchefstroom, South Africa lbirkholtz@up.ac.za richard.haynes@nwu.ac.za.
Groote Schuur Hospital · ZANorth-West University · ZAUniversity of Cape Town · ZAUniversity of Milan · ITHong Kong University of Science and Technology · HK
Funding
No grant is acknowledged in the PubMed record.
Abstract
The emergence of resistance toward artemisinin combination therapies (ACTs) by the malaria parasite
Indexed as
AntimalarialsArtemisininsDrug SynergismOxidation-ReductionOxidative StressPlasmodium falciparumReactive Oxygen SpeciesAntimalarialsartemisininArtemisininsartemisoneReactive Oxygen Speciesartemisininsgametocytesoxidative stressPlasmodium falciparumreactive oxygen speciessynergism
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.