Evidence map›Paper›PMID 29866864›Full record

ArticleAntimicrobial agents and chemotherapy2018

Linezolid Kills Acid-Phase and Nonreplicative-Persister-Phase Mycobacterium tuberculosis in a Hollow-Fiber Infection Model.

G L Drusano, Jenny Myrick, Michael Maynard, Jocelyn Nole, Brandon Duncanson, David Brown, Stephan Schmidt, Michael Neely, C A Scanga, Charles Peloquin and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 30 citations in OpenAlex.

  1. Article
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  4. DynamicAntibiotics (Basel, Switzerland) · 2024
    Review
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  16. Article
  17. Activity of Moxifloxacin againstAntimicrobial agents and chemotherapy · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

G L DrusanoInstitute for Therapeutic Innovation, College of Medicine, University of Florida, Lake Nona, Florida, USA gdrusano@ufl.edu.
Jenny MyrickInstitute for Therapeutic Innovation, College of Medicine, University of Florida, Lake Nona, Florida, USA.
Michael MaynardInstitute for Therapeutic Innovation, College of Medicine, University of Florida, Lake Nona, Florida, USA.
Jocelyn NoleInstitute for Therapeutic Innovation, College of Medicine, University of Florida, Lake Nona, Florida, USA.
Brandon DuncansonInstitute for Therapeutic Innovation, College of Medicine, University of Florida, Lake Nona, Florida, USA.
David BrownInstitute for Therapeutic Innovation, College of Medicine, University of Florida, Lake Nona, Florida, USA.
Stephan SchmidtInfectious Disease Pharmacokinetics Laboratory, University of Florida College of Pharmacy, Gainesville, Florida, USA.
Michael NeelyDivision of Pediatric Infectious Diseases, Children's Hospital of Los Angeles, University of Southern California, Los Angeles, California, USA.
C A ScangaDepartment of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Charles PeloquinInfectious Disease Pharmacokinetics Laboratory, University of Florida College of Pharmacy, Gainesville, Florida, USA.ORCID 0000-0001-9002-7052
Arnold LouieInstitute for Therapeutic Innovation, College of Medicine, University of Florida, Lake Nona, Florida, USA.
University of Florida · USUniversity of Pittsburgh · USUniversity of Southern California · US

Funding

Optimizing Combination Therapy to Accelerate Clinical Cure of TuberculosisP01AI123036 · NIAID · UNIVERSITY OF FLORIDA · PI FLYNN, JOANNE L. · 2016 to 2020
$12.0M
NIAID NIH HHS P01 AI123036
6 · The paper itself

Abstract

The therapy for treatment of

Indexed as

Models, BiologicalModels, StatisticalAnimalsAntitubercular AgentsArea Under CurveDiffusion Chambers, CultureDrug Administration ScheduleDrug Dosage CalculationsHumansLinezolidMycobacterium tuberculosisTuberculosisAntitubercular AgentsLinezolidacid phasehollow-fiber infection modellinezolidnonreplicative-persister phase

Identifiers

PMID29866864
PMCPMC6105790
OpenAlexW2807166367

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.