ArticleProceedings of the National Academy of Sciences of the United States of America2018
TMS-induced neuronal plasticity enables targeted remodeling of visual cortical maps.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 53 citations in OpenAlex.
- Transcranial magnetic stimulation in the treatment of adolescent depression: a systematic review and meta-analysis of aggregated and individual-patient data from uncontrolled studies.European child & adolescent psychiatry · 2022Pooled it
- Non-invasive brain stimulation as therapy: systematic review and recommendations with a focus on the treatment of Tourette syndrome.Experimental brain research · 2022Pooled it
- Theta burst stimulation of extrastriate body area for body perception in anorexia nervosa: a randomized controlled trial.Translational psychiatry · 2026Trial
- Targeted visual cortex stimulation (TVCS): a novel neuro-navigated repetitive transcranial magnetic stimulation mode for improving cognitive function in bipolar disorder.Translational psychiatry · 2023Trial
- Interneuron and glial mechanisms underlying V1 orientation map dynamics.IBRO neuroscience reports · 2026Article
- Perirhinal cortex abnormalities impair hippocampal plasticity and learning inScience advances · 2025Article
- Decoding auditory working memory content from EEG aftereffects of auditory-cortical TMS.bioRxiv : the preprint server for biology · 2025Article
- Review
- Theta-burst direct electrical stimulation remodels human brain networks.Nature communications · 2024Article
- Induction of excitatory brain state governs plastic functional changes in visual cortical topology.Brain structure & function · 2024Review
- Coordinated reset stimulation of plastic neural networks with spatially dependent synaptic connections.Frontiers in network physiology · 2024Article
- Repetitive transcranial magnetic stimulation (rTMS) triggers dose-dependent homeostatic rewiring in recurrent neuronal networks.PLoS computational biology · 2023Article
- Parcellation-Based Connectivity Model of the Judgement Core.Journal of personalized medicine · 2023Article
- Subject-specific whole-brain parcellations of nodes and boundaries are modulated differently under 10 Hz rTMS.Scientific reports · 2023Article
- The phase of plasticity-induced neurochemical changes of high-frequency repetitive transcranial magnetic stimulation are different from visual perceptual learning.Scientific reports · 2023Article
- Cortical excitability in human somatosensory and visual cortex: implications for plasticity and learning - a minireview.Frontiers in human neuroscience · 2023Review
- Targeted neuroplasticity in spatiotemporally patterned invasive neuromodulation therapies for improving clinical outcomes.Frontiers in neuroinformatics · 2023Article
- Article
- Synaptic reshaping of plastic neuronal networks by periodic multichannel stimulation with single-pulse and burst stimuli.PLoS computational biology · 2022Article
- Transcranial magnetic stimulation of the brain: What is stimulated? - A consensus and critical position paper.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2022Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Transcranial magnetic stimulation (TMS) has become a popular clinical method to modify cortical processing. The events underlying TMS-induced functional changes remain, however, largely unknown because current noninvasive recording methods lack spatiotemporal resolution or are incompatible with the strong TMS-associated electrical field. In particular, an answer to the question of how the relatively unspecific nature of TMS stimulation leads to specific neuronal reorganization, as well as a detailed picture of TMS-triggered reorganization of functional brain modules, is missing. Here we used real-time optical imaging in an animal experimental setting to track, at submillimeter range, TMS-induced functional changes in visual feature maps over several square millimeters of the brain's surface. We show that high-frequency TMS creates a transient cortical state with increased excitability and increased response variability, which opens a time window for enhanced plasticity. Visual stimulation (i.e., 30 min of passive exposure) with a single orientation applied during this TMS-induced permissive period led to enlarged imprinting of the chosen orientation on the visual map across visual cortex. This reorganization was stable for hours and was characterized by a systematic shift in orientation preference toward the trained orientation. Thus, TMS can noninvasively trigger a targeted large-scale remodeling of fundamentally mature functional architecture in early sensory cortex.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.