Evidence map›Paper›PMID 29866800›Full record

ArticleJournal of the American Society of Nephrology : JASN2018

IL-10 Receptor Signaling Empowers Regulatory T Cells to Control Th17 Responses and Protect from GN.

Paul Diefenhardt, Anna Nosko, Malte A Kluger, Johannes V Richter, Claudia Wegscheid, Yasushi Kobayashi, Gisa Tiegs, Samuel Huber, Richard A Flavell, Rolf A K Stahl and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in Journal of the American Society of Nephrology : JASN, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 1 pooled it
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 1 synthesis or guideline pooled it, 54 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. [Research Progress of Peripheral Immune Tolerance in Oral Diseases].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2026
    Review
  5. Article
  6. Review
  7. Article
  8. Occurrence and role of Tph cells in various renal diseases.Molecular medicine (Cambridge, Mass.) · 2024
    Review
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. The role of IL-33/ST2 signaling in the tumor microenvironment and Treg immunotherapy.Experimental biology and medicine (Maywood, N.J.) · 2022
    Review
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Paul DiefenhardtIII. Medizinische Klinik.
Anna NoskoIII. Medizinische Klinik.
Malte A KlugerIII. Medizinische Klinik.
Johannes V RichterIII. Medizinische Klinik.
Claudia WegscheidInstitut für Experimentelle Immunologie und Hepatologie, and.
Yasushi KobayashiDepartment of Immunobiology and The Howard Hughes Medical Institute, Yale School of Medicine, New Haven, Connecticut.
Gisa TiegsInstitut für Experimentelle Immunologie und Hepatologie, and.
Samuel HuberDepartment of Immunobiology and The Howard Hughes Medical Institute, Yale School of Medicine, New Haven, Connecticut.
Richard A FlavellDepartment of Immunobiology and The Howard Hughes Medical Institute, Yale School of Medicine, New Haven, Connecticut.
Rolf A K StahlIII. Medizinische Klinik.
Oliver M SteinmetzIII. Medizinische Klinik, o.steinmetz@uke.de.
Howard Hughes Medical Institute · USUniversity Medical Center Hamburg-Eppendorf · DE

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Signal TransductionAnimalsCell DifferentiationCytokinesDendritic CellsDisease Models, AnimalDown-RegulationGlomerulonephritisInterleukin-10Interleukin-10 Receptor alpha SubunitMaleMiceMice, KnockoutNephritisReceptors, CCR6Th17 CellsCCR6 protein, mouseCytokinesIL10 protein, mouseInterleukin-10Interleukin-10 Receptor alpha SubunitReceptors, CCR6cytokinesglomerulonephritisIL-10RIL-17Interleukin 10Treg

Identifiers

PMID29866800
PMCPMC6050938
OpenAlexW2806991280

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.