Evidence map›Paper›PMID 29866742›Full record

ArticleHypertension (Dallas, Tex. : 1979)2018

Angiotensin II-Induced End-Organ Damage in Mice Is Attenuated by Human Exosomes and by an Exosomal Y RNA Fragment.

Linda Cambier, Jorge F Giani, Weixin Liu, Takeshi Ijichi, Antonio K Echavez, Jackelyn Valle, Eduardo Marbán

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Hypertension (Dallas, Tex. : 1979), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed, 2 pooled it
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 2 syntheses or guidelines pooled it, 70 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Dissecting the small RNA code of inflammatory bowel disease.Molecular medicine (Cambridge, Mass.) · 2026
    Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. Review
  12. Article
  13. Review
  14. Article
  15. Article
  16. Review
  17. Review
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Linda CambierFrom the Smidt Heart Institute (L.C., W.L., T.I., A.K.E., J.V., E.M.).
Jorge F GianiDepartment of Biomedical Sciences (L.C., J.F.G.), Cedars-Sinai Medical Center, Los Angeles, CA.
Weixin LiuFrom the Smidt Heart Institute (L.C., W.L., T.I., A.K.E., J.V., E.M.).
Takeshi IjichiFrom the Smidt Heart Institute (L.C., W.L., T.I., A.K.E., J.V., E.M.).
Antonio K EchavezFrom the Smidt Heart Institute (L.C., W.L., T.I., A.K.E., J.V., E.M.).
Jackelyn ValleFrom the Smidt Heart Institute (L.C., W.L., T.I., A.K.E., J.V., E.M.).
Eduardo MarbánFrom the Smidt Heart Institute (L.C., W.L., T.I., A.K.E., J.V., E.M.) Eduardo.Marban@cshs.org.
Cedars-Sinai Smidt Heart Institute · US

Funding

Exosome-mediated cardioprotection and regenerationR01HL124074 · NHLBI · CEDARS-SINAI MEDICAL CENTER · PI MARBAN, EDUARDO · 2014 to 2021
$4.0M
NHLBI NIH HHS R01 HL124074
6 · The paper itself

Abstract

Hypertension often leads to cardiovascular disease and kidney dysfunction. Exosomes secreted from cardiosphere-derived cells (CDC-exo) and their most abundant small RNA constituent, the Y RNA fragment EV-YF1, exert therapeutic benefits after myocardial infarction. Here, we investigated the effects of CDC-exo and EV-YF1, each administered individually, in a model of cardiac hypertrophy and kidney injury induced by chronic infusion of Ang (angiotensin) II. After 2 weeks of Ang II, multiple doses of CDC-exo or EV-YF1 were administered retro-orbitally. Ang II infusion induced an elevation in systolic blood pressure that was not affected by CDC-exo or EV-YF1. Echocardiography confirmed that Ang II infusion led to cardiac hypertrophy. CDC-exo and EV-YF1 both attenuated cardiac hypertrophy and reduced cardiac inflammation and fibrosis. In addition, both CDC-exo and EV-YF1 improved kidney function and diminished renal inflammation and fibrosis. The beneficial effects of CDC-exo and EV-YF1 were associated with changes in the expression of the anti-inflammatory cytokine IL (interleukin)-10 in plasma, heart, spleen, and kidney. In summary, infusions of CDC-exo or EV-YF1 attenuated cardiac hypertrophy and renal injury induced by Ang II infusion, without affecting blood pressure, in association with altered IL-10 expression. Exosomes and their defined noncoding RNA contents may represent potential new therapeutic approaches for hypertension-associated cardiovascular and renal damage.

Indexed as

Acute Kidney InjuryAngiotensin IIAnimalsCells, CulturedDisease Models, AnimalExosomesHumansHypertensionInterleukin-10MaleMiceMice, Inbred C57BLMyocytes, CardiacRNAAngiotensin IIInterleukin-10RNAangiotensin IIexosomeskidneymacrophagesrisk factors

Identifiers

PMID29866742
PMCPMC6043385
OpenAlexW2805175202

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.