SynthesisBMJ open2018
Interpregnancy weight change and adverse pregnancy outcomes: a systematic review and meta-analysis.
Synthesis in BMJ open, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 4 syntheses or guidelines pooled it, 68 citations in OpenAlex.
- Global trends in prevalence of maternal overweight and obesity: A systematic review and meta-analysis of routinely collected data retrospective cohorts.International journal of population data science · 2024Pooled it
- Pooled it
- The impact of interpregnancy weight change on perinatal outcomes in women and their children: A systematic review and meta-analysis.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2020Pooled it
- Effect of interpregnancy weight change on perinatal outcomes: systematic review and meta-analysis.BMC pregnancy and childbirth · 2019Pooled it
- An interim analysis of a gestational weight gain intervention in military personnel and other TRICARE beneficiaries.Obesity (Silver Spring, Md.) · 2022Trial
- Evaluating Weight and Body Mass Index Changes in Women Conceiving with Assisted Reproductive Technologies in Consecutive Pregnancies: A Retrospective Cohort Study.Maternal and child health journal · 2026Article
- Preconception Weight Change and Pregnancy Outcomes After Bariatric Surgery.Journal of clinical medicine · 2026Article
- Low-normal birthweight in the first pregnancy as a risk factor for small for gestational age in the second pregnancy: A matched case-control study.Pregnancy (Hoboken, N.J.) · 2026Article
- Knowledge Gaps Regarding Overweight and Obesity in Pregnancy: A Cross-Sectional Study Among Polish Women.Nutrients · 2026Article
- Maternal and Interpregnancy Factors and Risks of First-Time Preeclampsia in Second Pregnancy: A Swedish National Cohort Study.BJOG : an international journal of obstetrics and gynaecology · 2026Article
- Postpartum Body Composition in Women With Overweight: Associations With Diet During Pregnancy.Obesity science & practice · 2025Article
- Interpregnancy Weight Change and Adverse Birth Outcomes: Cohort Study Using Brazil's Routine Register-Based Linked Data.Maternal & child nutrition · 2025Article
- Article
- Interpregnancy maternal weight change is not associated with offspring weight and obesity at age 2 years.International journal of obesity (2005) · 2024Article
- Gestational weight trajectory and risk of adverse pregnancy outcomes among women with gestational diabetes mellitus: A retrospective cohort study.Maternal & child nutrition · 2024Article
- Article
- Impact of interpregnancy weight changes and perinatal outcomes: A retrospective study in Japan.PloS one · 2024Article
- Interpregnancy weight change and risks of stillbirth and infant mortality: a protocol of a systematic review and meta-analysis.BMJ open · 2023Article
- Article
- A pre-conception clinical trial to reduce intergenerational obesity and diabetes risks: The NDPP-NextGen trial protocol.Contemporary clinical trials · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
objectivesTo evaluate the effect of interpregnancy body mass index (BMI) change on pregnancy outcomes, including large-for-gestational-age babies (LGA), small-for-gestational-age babies (SGA), macrosomia, gestational diabetes mellitus (GDM) and caesarean section (CS).
designSystematic review and meta-analysis of observational cohort studies. DATA SOURCES: Literature searches were performed across Cochrane, MEDLINE, EMBASE, CINAHL, Global Health and MIDIRS databases. STUDY SELECTION: Observational cohort studies with participants parity from 0 to 1.
main outcome measuresAdjusted ORs (aORs) with 95% CIs were used to evaluate the association between interpregnancy BMI change on five outcomes.
results925 065 women with singleton births from parity 0 to 1 were included in the meta-analysis of 11 studies selected from 924 identified studies. A substantial increase in interpregnancy BMI (>3 BMI units) was associated with an increased risk of LGA (aOR 1.85, 95% CI 1.71 to 2.00, p<0.001), GDM (aOR 2.28, 95% CI 1.97 to 2.63, p<0.001), macrosomia (aOR 1.54, 95% CI 0.939 to 2.505) and CS (aOR 1.72, 95% CI 1.32 to 2.24, p<0.001) compared with the reference category, and a decreased risk of SGA (aOR 0.83, 95% CI 0.70 to 0.99, p=0.044). An interpregnancy BMI decrease was associated with a decreased risk of LGA births (aOR 0.70, 95% CI 0.55 to 0.90, p<0.001) and GDM (aOR 0.80, 95% CI 0.62 to 1.03), and an increased risk of SGA (aOR 1.31, 95% CI 1.06 to 1.63, p=0.014). Women with a normal BMI (<25kg/m
conclusionsGaining weight between pregnancies increases risk of developing GDM, CS and LGA, and reduces risk of SGA in the subsequent pregnancy. Losing weight between pregnancies reduces risk of GDM and LGA and increases risk of SGA. Weight stability between first and second pregnancy is advised in order to reduce risk of adverse outcomes. TRIAL REGISTRATION NUMBER: CRD42016041299.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.