SynthesisJournal of neurology, neurosurgery, and psychiatry2018
Serum antigliadin antibodies in cerebellar ataxias: a systematic review and meta-analysis.
Synthesis in Journal of neurology, neurosurgery, and psychiatry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- Cerebellar Symptoms in Gluten Sensitivity: a Systematic Review of the Effect of a Gluten-Free Diet on Brain Imaging.Cerebellum (London, England) · 2022Pooled it
- Presumptive paroxysmal dyskinesia in 41 dogs: is the diet change enough?Journal of veterinary internal medicine · 2026Article
- Article
- Factors Affecting Gluten-Free Dietary Adherence in Patients with Neurological Gluten-Related Disease.Nutrients · 2026Article
- Persisting Transglutaminase 6 Antibodies in Neurological Gluten-Related Disorders.Annals of neurology · 2026Observational
- Letter to editors regarding "Serological analysis of gluten‑related antibodies in idiopathic neuropathies and cerebellar ataxia".Journal of neurology · 2025Article
- Serological analysis of gluten-related antibodies in idiopathic neuropathies and cerebellar ataxia.Journal of neurology · 2025Article
- Ataxia in a Movement Disorders Outpatient Clinic: a Single-Center Experience in Turkey.Cerebellum (London, England) · 2023Article
- Ataxias: Hereditary, Acquired, and Reversible Etiologies.Seminars in neurology · 2023Article
- Who to screen and how to screen for celiac disease.World journal of gastroenterology · 2022Review
- A Breakdown of Immune Tolerance in the Cerebellum.Brain sciences · 2022Review
- Severe ataxia uncovered Hodgkin's lymphoma: do not forget CT neck when looking for covert malignancy.BMJ case reports · 2021Article
- Neurological manifestation of coeliac disease with particular emphasis on gluten ataxia and immunological injury: a review article.Gastroenterology and hepatology from bed to bench · 2021Review
- Sporadic adult-onset spinocerebellar ataxias : Reply: Degenerative and acquired sporadic adult-onset ataxia https://doi.org/10.1007/s10072-019-03856-w.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2019Article
- Ataxia.Continuum (Minneapolis, Minn.) · 2019Review
- Diagnosis and management of progressive ataxia in adults.Practical neurology · 2019Review
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundGluten sensitivity refers to prominent immunological responses to gluten, usually in conjunction with elevated levels of serum antigliadin antibody (AGA). The association between AGA and cerebellar ataxias has been inconsistently reported.
methodsWe performed a systematic literature search and a meta-analysis to study the weighted pooled OR of idiopathic cerebellar ataxia (IDCA) cases to controls or to hereditary ataxia (HA) for AGA seropositivity using fixed effect model.
resultsEleven studies were included, with a total of 847 IDCA cases, 1654 controls and 445 HA cases. IDCA cases had fourfold higher odds than controls (OR 4.28, 95% CI 3.10 to 5.90) and twofold higher odds than HA cases (OR 2.23, 95% CI 1.45 to 3.44) of having AGA seropositivity. Sensitivity analysis excluding the most weighted study, which accounted for 69% of the total weight, still showed similar associations (IDCA vs controls, OR 3.18, 95% CI 1.79 to 5.67 and IDCA vs HA, OR 1.72, 95% CI 1.03 to 2.86, respectively). The subgroup analysis showed that, when compared with controls, IDCA cases of both East Asian and Western countries had approximately threefold to fourfold higher odds to have AGA seropositivity (OR 3.41, 95% CI 1.67 to 6.97 and OR 4.53, 95% CI 3.16 to 6.49, respectively), suggesting the lack of ethnic heterogeneity. The odds of AGA seropositivity for HA cases was not significantly higher than controls (OR 1.41, 95% CI 0.82 to 2.44).
conclusionOur study indicates the association between AGA and IDCA, across different geographic regions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.