Evidence map›Paper›PMID 29866703›Full record

ArticleThe EMBO journal2018

Live imaging of wound angiogenesis reveals macrophage orchestrated vessel sprouting and regression.

David B Gurevich, Charlotte E Severn, Catherine Twomey, Alexander Greenhough, Jenna Cash, Ashley M Toye, Harry Mellor, Paul Martin

Open access · hybridAbstract read
In one paragraph

Article in The EMBO journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 147 papers.

0numbers the graph read from it
0cells of the map it votes in
147citing papers in PubMed
9.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

147 citing papers in PubMed, 274 citations in OpenAlex.

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  11. Harnessing population genetics and animal models to uncover the genetics of skin scarring.Journal of plastic, reconstructive & aesthetic surgery : JPRAS · 2026
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  16. M2c Macrophages Mediate YAP1 to Promote Vascularized Bone Regeneration in Distraction Osteogenesis.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Article
  17. Affinity-based controlled release of interleukin-4 from scaffolds via biotin-streptavidin interactions for immunomodulation.Journal of controlled release : official journal of the Controlled Release Society · 2025
    Article
  18. Macrophages at the Crossroads of Chronic Stress and Cancer.International journal of molecular sciences · 2025
    Review
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  20. Article

87 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

David B GurevichSchool of Biochemistry, University of Bristol, Bristol, UK.
Charlotte E SevernSchool of Biochemistry, University of Bristol, Bristol, UK.
Catherine TwomeySchool of Biochemistry, University of Bristol, Bristol, UK.
Alexander GreenhoughSchool of Cellular and Molecular Medicine, University of Bristol, Bristol, UK.
Jenna CashSchool of Biochemistry, University of Bristol, Bristol, UK.
Ashley M ToyeSchool of Biochemistry, University of Bristol, Bristol, UK.ORCID 0000-0003-4395-9396
Harry MellorSchool of Biochemistry, University of Bristol, Bristol, UK.
Paul MartinSchool of Biochemistry, University of Bristol, Bristol, UK paul.martin@bristol.ac.uk.ORCID 0000-0002-2665-5086
University of Bristol · GBNational Institute for Health Research · GBNHS Blood and Transplant · GB

Funding

British Heart Foundation PG/16/62/32295Cancer Research UK C19/A11975Wellcome Trust 102390/Z/13/ZWellcome Trust 202581/Z/16/ZWellcome Trust WT097791/Z11/Z
6 · The paper itself

Abstract

Wound angiogenesis is an integral part of tissue repair and is impaired in many pathologies of healing. Here, we investigate the cellular interactions between innate immune cells and endothelial cells at wounds that drive neoangiogenic sprouting in real time and

Indexed as

Neovascularization, PhysiologicAnimalsAnimals, Genetically ModifiedCells, CulturedDiagnostic ImagingFibroblastsHumansHuman Umbilical Vein Endothelial CellsMacrophagesMaleMice, Inbred C57BLWound HealingZebrafishangiogenesisinflammationmacrophagesneutrophilswound

Identifiers

PMID29866703
PMCPMC6028026
OpenAlexW2806159238

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.