Evidence map›Paper›PMID 29866434›Full record

ReviewJournal of magnetic resonance (San Diego, Calif. : 1997)2018

Quantitative imaging of brain energy metabolisms and neuroenergetics using in vivo X-nuclear

Xiao-Hong Zhu, Ming Lu, Wei Chen

Abstract readReview
In one paragraph

Review in Journal of magnetic resonance (San Diego, Calif. : 1997), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Systematic review ofFrontiers in aging neuroscience · 2023
    Pooled it
  3. Review
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  7. Review
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  13. Review
  14. Frequency-independent dual-tuned cable traps for multi-nuclear MRI and MRS.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2024
    Article
  15. Leveraging ultra-high field (7T) MRI in psychiatric research.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024
    Review
  16. Skeletal muscle dysfunction in amyotrophic lateral sclerosis: a mitochondrial perspective and therapeutic approaches.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024
    Review
  17. Article
  18. Article
  19. Article
  20. Nature biomedical engineering · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Xiao-Hong ZhuCenter for Magnetic Resonance Research, Department of Radiology, University of Minnesota, School of Medicine, Minneapolis, MN 55455, USA.
Ming LuCenter for Magnetic Resonance Research, Department of Radiology, University of Minnesota, School of Medicine, Minneapolis, MN 55455, USA.
Wei ChenCenter for Magnetic Resonance Research, Department of Radiology, University of Minnesota, School of Medicine, Minneapolis, MN 55455, USA. Electronic address: wei@cmrr.umn.edu.

Funding

NMR Imaging and SpectroscopyP41EB015894 · NIBIB · UNIVERSITY OF MINNESOTA · PI UGURBIL, KAMIL · 2012 to 2017
$8.4M
Neurons, Vessels and Voxels: Multi-modal Imaging of Layer Specific SignalsR01MH111447 · NIMH · UNIVERSITY OF MINNESOTA · PI KARA, PRAKASH, NASELARIS, THOMAS P · 2016 to 2020
$5.0M
Integrated fMRI Methods to Study Neurophysiology and Circuit Dynamics at Laminar and Columnar LevelR01MH111413 · NIMH · UNIVERSITY OF MINNESOTA · PI CHEN, WEI · 2016 to 2020
$4.4M
Institutional Center Cores for Advanced NeuroimagingP30NS076408 · NINDS · UNIVERSITY OF MINNESOTA · PI UGURBIL, KAMIL · 2012 to 2020
$4.2M
Noninvasive Study of Cerebral ATP Metabolism, Bioenergetics and Brain FunctionR01NS057560 · NINDS · UNIVERSITY OF MINNESOTA · PI CHEN, WEI · 2009 to 2013
$2.8M
Quantitative and Non-invasive Imaging of Oxygen Metabolism in Human BrainR01NS070839 · NINDS · UNIVERSITY OF MINNESOTA · PI ZHU, XIAO-HONG · 2010 to 2014
$2.2M
Advancing MRI & MRS Technologies for Studying Human Brain Function and EnergeticsR24MH106049 · NIMH · UNIVERSITY OF MINNESOTA · PI CHEN, WEI, YANG, QING X · 2014 to 2016
$1.6M
NIBIB NIH HHS P41 EB015894NIMH NIH HHS R01 MH111413NIMH NIH HHS R01 MH111447NIMH NIH HHS R24 MH106049NINDS NIH HHS P30 NS076408NINDS NIH HHS R01 NS057560NINDS NIH HHS R01 NS070839
6 · The paper itself

Abstract

Brain energy metabolism relies predominantly on glucose and oxygen utilization to generate biochemical energy in the form of adenosine triphosphate (ATP). ATP is essential for maintaining basal electrophysiological activities in a resting brain and supporting evoked neuronal activity under an activated state. Studying complex neuroenergetic processes in the brain requires sophisticated neuroimaging techniques enabling noninvasive and quantitative assessment of cerebral energy metabolisms and quantification of metabolic rates. Recent state-of-the-art in vivo X-nuclear MRS techniques, including

Indexed as

Adenosine TriphosphateAnimalsBrainDeuteriumElectromagnetic FieldsEnergy MetabolismHumansMagnetic Resonance ImagingMagnetic Resonance SpectroscopyOxygen IsotopesPhosphorus IsotopesAdenosine TriphosphateDeuteriumOxygen IsotopesPhosphorus IsotopesBrain energy metabolismCerebral metabolic rate of glucose (CMR(Glc)) and oxygen (CMRO(2)) consumption, and ATP production (CMR(ATP))In vivo X-nuclear MRS and imagingNAD redox stateNeuroenergeticsTCA cycle rate (V(TCA))Ultra-high magnetic field (UHF)

Identifiers

PMID29866434
PMCPMC5996770

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.