Evidence map›Paper›PMID 29866335›Full record

ArticlePhysica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB)2018

Quantifying the robustness of [

Maria Luisa Belli, Martina Mori, Sara Broggi, Giovanni Mauro Cattaneo, Valentino Bettinardi, Italo Dell'Oca, Federico Fallanca, Paolo Passoni, Emilia Giovanna Vanoli, Riccardo Calandrino and 3 more

Registry-linked trialAbstract read
PubMed Publisher
In one paragraph

Article in Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03967951 (CT Radiomic Features of Pancreatic Neuroendocrine Neoplasms), which is not on this map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03967951 completednot on this mapstarted 2019, after this paper: background citation

CT Radiomic Features of Pancreatic Neuroendocrine Neoplasms

TypeobservationalSponsorFrancesco De CobelliRan2019 to 2019Enrolled70ConditionsPancreatic Neuroendocrine TumorArmsCT radiomic feature evaluation
3 · Its place in the literature

Who cites it

34 citing papers in PubMed.

  1. Article
  2. Article
  3. Multicentric development and evaluation of [European journal of nuclear medicine and molecular imaging · 2024
    Article
  4. Article
  5. Article
  6. Multicentric development and evaluation ofEuropean journal of nuclear medicine and molecular imaging · 2023
    Article
  7. Review
  8. CT radiomic predictors of local relapse after SBRT for lung oligometastases from colorectal cancer: a single institute pilot study.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2023
    Article
  9. External validation of anEuropean journal of nuclear medicine and molecular imaging · 2023
    Article
  10. Article
  11. Radiomics: a primer on high-throughput image phenotyping.Abdominal radiology (New York) · 2022
    Review
  12. Review
  13. Article
  14. Quantitative Radiomics Features in Diffuse Large B-Cell Lymphoma: Does Segmentation Method Matter?Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2022
    Article
  15. Article
  16. Review
  17. Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Maria Luisa BelliMedical Physics, San Raffaele Scientific Institute, Milano, Italy.
Martina MoriMedical Physics, San Raffaele Scientific Institute, Milano, Italy.
Sara BroggiMedical Physics, San Raffaele Scientific Institute, Milano, Italy.
Giovanni Mauro CattaneoMedical Physics, San Raffaele Scientific Institute, Milano, Italy.
Valentino BettinardiNuclear Medicine, San Raffaele Scientific Institute, Milano, Italy.
Italo Dell'OcaRadiotherapy, San Raffaele Scientific Institute, Milano, Italy.
Federico FallancaNuclear Medicine, San Raffaele Scientific Institute, Milano, Italy.
Paolo PassoniRadiotherapy, San Raffaele Scientific Institute, Milano, Italy.
Emilia Giovanna VanoliNuclear Medicine, San Raffaele Scientific Institute, Milano, Italy.
Riccardo CalandrinoMedical Physics, San Raffaele Scientific Institute, Milano, Italy.
Nadia Di MuzioRadiotherapy, San Raffaele Scientific Institute, Milano, Italy.
Maria PicchioNuclear Medicine, San Raffaele Scientific Institute, Milano, Italy.
Claudio FiorinoMedical Physics, San Raffaele Scientific Institute, Milano, Italy. Electronic address: fiorino.claudio@hsr.it.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo investigate the robustness of PET radiomic features (RF) against tumour delineation uncertainty in two clinically relevant situations.

methodsTwenty-five head-and-neck (HN) and 25 pancreatic cancer patients previously treated with

resultsA large disagreement between manual and SUV_max method was found for thresholds  ≥50%. Inter-observer variability showed median DICE values between 0.81 (HN-T) and 0.73 (pancreas). Volumes defined by PET_Edge were better consistent with the manual ones compared to SUV40%. Regarding RF, 19%/19%/47% of the features showed ICC < 0.80 between observers for HN-N/HN-T/pancreas, mostly in the Voxel-alignment matrix and in the intensity-size zone matrix families. RFs with ICC < 0.80 against manual delineation (taking the worst value) increased to 44%/36%/61% for PET_Edge and to 69%/53%/75% for SUV40%.

conclusionsAbout 80%/50% of 72 RF were consistent between observers for HN/pancreas patients. PET_edge was sufficiently robust against manual delineation while SUV40% showed a worse performance. This result suggests the possibility to replace manual with semi-automatic delineation of HN and pancreas tumours in studies including PET radiomic analyses.

Indexed as

Fluorodeoxyglucose F18Positron Emission Tomography Computed TomographyHead and Neck NeoplasmsHumansImage Processing, Computer-AssistedPancreatic NeoplasmsFluorodeoxyglucose F18Head-and-neck cancerPancreas cancerPETRadiomicTexture analysis

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.