ArticleBMC complementary and alternative medicine2018
Antioxidant, anticholinesterase and antifatigue effects of Trichilia catigua (catuaba).
Article in BMC complementary and alternative medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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10 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- Neurocognitive effects of proanthocyanidin in Alzheimer's disease: a systematic review of preclinical evidence.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2024Pooled it
- Metabolomic Profile, Antioxidant Capacity, and Preliminary Cellular Activity ofMolecules (Basel, Switzerland) · 2026Article
- Simultaneous inhibition of cholinesterase and antagonism of histamine H3 receptors alleviates cognitive deficits and mitigates apoptosis in scopolamine-induced amnesia in mice.Frontiers in behavioral neuroscience · 2026Article
- Antifatigue effects and antioxidant activity in polysaccharide fractions from ChineseFood science & nutrition · 2024Article
- Determination of Anti-Alzheimer's Disease Activity of Selected Plant Ingredients.Molecules (Basel, Switzerland) · 2022Review
- Anti-Fatigue and Exercise Performance Improvement Effect ofNutrients · 2022Article
- Procyanidins: From Agro-Industrial Waste to Food as Bioactive Molecules.Foods (Basel, Switzerland) · 2021Review
- In silico approach of secondary metabolites from Brazilian herbal medicines to search for potential drugs against SARS-CoV-2.Phytotherapy research : PTR · 2021Review
- Fermented Deer Blood Ameliorates Intense Exercise-Induced Fatigue via Modulating Small Intestine Microbiota and Metabolites in Mice.Nutrients · 2021Article
- Soursop fruit extract mitigates scopolamine-induced amnesia and oxidative stress via activating cholinergic and Nrf2/HO-1 pathways.Metabolic brain disease · 2019Article
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6 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundTrichilia catigua A. Juss. (Meliaceae) is a species known as catuaba and used in folk medicine for the treatment of fatigue, stress, impotence and memory deficit. The main phytochemical compounds identified in the barks of T. catigua are flavalignans, flavan-3-ols and flavonoids which are associated with its antioxidant activity. Pre-clinical studies with T. catigua extracts have identified many pharmacological properties, such as anti-inflammatory, antidepressant, antinociceptive, pro-memory and neuroprotective against ischemia and oxidative stress. This study was designed in order to compare the chemical composition and in vitro antioxidant and anticholinesterase activity of four different polarity extracts and selected the one most active for in vivo studies in rodent models of stress, fatigue and memory.
methodsHexane, chloroform, hydroalcoholic and aqueous extracts from bark of Trichilia catigua were analyzed by RPHPLC-DAD-ESI-MS/MS. Antioxidant activity was assessed by 2,2-diphenyl-1-picryl hydrazyl (DPPH) assay and acetylcholinesterase inhibition by Ellman's modified method. In vivo studies (stress, fatigue and memory) were carried out with adult male mice and rats treated with hydroalcoholic extract in doses of 25-300 mg/kg (p.o.).
resultsWe confirmed the presence of cinchonain IIa, Ia and Ib, as main constituents in the four extracts, while procyanidins were detected only in hydroalcoholic extract. Antioxidant and anticholinesterase activity were observed for all extracts, with most potent activity found on the hydroalcoholic extract (EC
conclusionsThese data suggest the hydroalcoholic extract as the most suitable for plant extraction and partially support the folk use of T. catigua as antifatigue drug. . Trichilia catigua hydroalcoholic extract exhibits antioxidant and anticholinesterase activity in vitro and reduces the fatigue induced by forced exercise.
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