Evidence map›Paper›PMID 29866104›Full record

ArticleBMC infectious diseases2018

Clinical and bacteriological features and prognosis of ascitic fluid infection in Chinese patients with cirrhosis.

Nian-Zhi Ning, Tao Li, Ju-Ling Zhang, Fen Qu, Jie Huang, Xiong Liu, Zhan Li, Wei Geng, Jun-Liang Fu, Wang Huan and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC infectious diseases, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Antibiotic treatment in cirrhotic patients.World journal of clinical cases · 2023
    Article
  8. Review
  9. Article
  10. [Pathogenic bacteria characteristics and antimicrobial treatment plan for liver cirrhosis combined with spontaneous bacterial peritonitis].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2021
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. [Expert consensus on diagnosis and treatment of end-stage liver disease complicated with infections].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Nian-Zhi NingThe State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, No.20 Dongda Street, Fengtai District, Beijing, 100071, China.
Tao LiThe State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, No.20 Dongda Street, Fengtai District, Beijing, 100071, China.
Ju-Ling ZhangClinical Diagnostic Center, Beijing 302 Hospital, No. 100 Western 4th Middle Ring Road, Beijing, 100039, China.
Fen QuClinical Diagnostic Center, Beijing 302 Hospital, No. 100 Western 4th Middle Ring Road, Beijing, 100039, China.
Jie HuangThe State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, No.20 Dongda Street, Fengtai District, Beijing, 100071, China.
Xiong LiuThe State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, No.20 Dongda Street, Fengtai District, Beijing, 100071, China.
Zhan LiThe State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, No.20 Dongda Street, Fengtai District, Beijing, 100071, China.
Wei GengClinical Diagnostic Center, Beijing 302 Hospital, No. 100 Western 4th Middle Ring Road, Beijing, 100039, China.
Jun-Liang FuResearch Center for Biological Therapy, Institute of Translational Hepatology, Beijing 302 Hospital, Beijing, 100039, China.
Wang HuanClinical Diagnostic Center, Beijing 302 Hospital, No. 100 Western 4th Middle Ring Road, Beijing, 100039, China.
Shu-Yong ZhangClinical Diagnostic Center, Beijing 302 Hospital, No. 100 Western 4th Middle Ring Road, Beijing, 100039, China.
Chun-Mei BaoClinical Diagnostic Center, Beijing 302 Hospital, No. 100 Western 4th Middle Ring Road, Beijing, 100039, China. bcm2003@sina.com.
Hui WangThe State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, No.20 Dongda Street, Fengtai District, Beijing, 100071, China. geno0109@vip.sina.com.
302 Military Hospital of China · CNInstitute of Microbiology · CN

Funding

National Key Basic Research Program (973) of China 2015CB554202National Natural Science Foundation of China 81401643science and technology plan program of Beijing, China Z151100003915151State Key Laboratory of Pathogen and Biosecurity Program SKLPBS1530State Key Research Development Program of China 2016YFC1200301
6 · The paper itself

Abstract

backgroundSpontaneous bacterial peritonitis (SBP) and bacterascites (BA) represent frequent and serious complications in cirrhosis patients with ascites. However, few detailed data are available regarding the clinical and bacteriological feature of SBP or BA patients in China.

methodsWe retrospectively analyzed bacteriological and clinical characteristics of patients with SBP and BA at Beijing 302 Hospital in China from January 2012 to December 2015.

resultsA total of 600 patients with SBP (n = 408) or BA (n = 192) were enrolled. Patients with BA appeared to have a less severe clinical manifestation and lower mortality rate than patients with SBP. Gram-negative bacteria formed the majority of pathogens in SBP (73.9%) and BA (55.8%) cases. Higher ascitic fluid polymorphonuclear leucocytes (PMN) count and hepatocellular carcinoma were independent risk factors for BA episode progressing to SBP. The concentration of blood urea nitrogen (BUN) was independent risk factor for 30-day mortality of BA patients. For patients with SBP, the independent risk factors for 30-day mortality were age, Model for End-Stage Liver Disease (MELD) score, septic shock and hepatocellular carcinoma. Patients with third-generation cephalosporin or carbapenems resistant infection had a significantly lower survival probability. There were significant differences in clinical characteristics and outcome among the major bacteria. Multivariate analysis showed that patients infected with Klebsiella spp. had higher hazard ratio of 30-day mortality.

conclusionOur study reported the bacteriological and clinical characteristics of patients with SBP and BA. Higher ascitic fluid PMN count and hepatocellular carcinoma were found to be independent risk factors for BA episode progressed to SBP. Outcome of ascitic fluid infection in patients with cirrhosis was influenced by the type of bacteria and antimicrobial susceptibility.

Indexed as

AdultAgedAscitesAscitic FluidAsian PeopleBacterial InfectionsCarcinoma, HepatocellularDrug Resistance, BacterialFemaleGram-Negative BacteriaHumansLiver CirrhosisLiver NeoplasmsMaleMiddle AgedPeritonitisBacterascitesCausative pathogensCirrhosisMortalityRisk factorSpontaneous bacterial peritonitis

Identifiers

PMID29866104
PMCPMC5987451
OpenAlexW2806668012

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.