Evidence map›Paper›PMID 29866037›Full record

ArticleBMC microbiology2018

Disbiome database: linking the microbiome to disease.

Yorick Janssens, Joachim Nielandt, Antoon Bronselaer, Nathan Debunne, Frederick Verbeke, Evelien Wynendaele, Filip Van Immerseel, Yves-Paul Vandewynckel, Guy De Tré, Bart De Spiegeleer

Abstract read
In one paragraph

Article in BMC microbiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 126 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
126citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

126 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  8. The gut as a central hub for multi-organ crosstalk in aging.Cellular and molecular life sciences : CMLS · 2026
    Review
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66 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yorick JanssensDrug Quality and Registration (DruQuaR) Group, Faculty of Pharmaceutical Sciences, Ghent University, Ottergemsesteenweg 460, B-9000, Ghent, Belgium.
Joachim NielandtDepartment of Telecommunications and Information Processing, Faculty of Engineering and Architecture, Ghent University, Sint-Pietersnieuwstraat 41, B-9000, Ghent, Belgium.
Antoon BronselaerDepartment of Telecommunications and Information Processing, Faculty of Engineering and Architecture, Ghent University, Sint-Pietersnieuwstraat 41, B-9000, Ghent, Belgium.
Nathan DebunneDrug Quality and Registration (DruQuaR) Group, Faculty of Pharmaceutical Sciences, Ghent University, Ottergemsesteenweg 460, B-9000, Ghent, Belgium.
Frederick VerbekeDrug Quality and Registration (DruQuaR) Group, Faculty of Pharmaceutical Sciences, Ghent University, Ottergemsesteenweg 460, B-9000, Ghent, Belgium.
Evelien WynendaeleDrug Quality and Registration (DruQuaR) Group, Faculty of Pharmaceutical Sciences, Ghent University, Ottergemsesteenweg 460, B-9000, Ghent, Belgium.
Filip Van ImmerseelDepartment of Pathology, Bacteriology and Poultry Diseases, Faculty of Veterinary Sciences, Ghent University, Salisburylaan 133, B-9820, Merelbeke, Belgium.
Yves-Paul VandewynckelDepartment of Internal Medicine, Hepatology Research Unit; Faculty of Medicine and Health Sciences, Ghent University, De Pintelaan 185, B-9000, Ghent, Belgium.
Guy De TréDepartment of Telecommunications and Information Processing, Faculty of Engineering and Architecture, Ghent University, Sint-Pietersnieuwstraat 41, B-9000, Ghent, Belgium.
Bart De SpiegeleerDrug Quality and Registration (DruQuaR) Group, Faculty of Pharmaceutical Sciences, Ghent University, Ottergemsesteenweg 460, B-9000, Ghent, Belgium. Bart.DeSpiegeleer@UGent.be.ORCID 0000-0002-7353-5300

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRecent research has provided fascinating indications and evidence that the host health is linked to its microbial inhabitants. Due to the development of high-throughput sequencing technologies, more and more data covering microbial composition changes in different disease types are emerging. However, this information is dispersed over a wide variety of medical and biomedical disciplines. DESCRIPTION: Disbiome is a database which collects and presents published microbiota-disease information in a standardized way. The diseases are classified using the MedDRA classification system and the micro-organisms are linked to their NCBI and SILVA taxonomy. Finally, each study included in the Disbiome database is assessed for its reporting quality using a standardized questionnaire.

conclusionsDisbiome is the first database giving a clear, concise and up-to-date overview of microbial composition differences in diseases, together with the relevant information of the studies published. The strength of this database lies within the combination of the presence of references to other databases, which enables both specific and diverse search strategies within the Disbiome database, and the human annotation which ensures a simple and structured presentation of the available data.

Indexed as

Databases, FactualMicrobiotaDysbiosisHigh-Throughput Nucleotide SequencingHumansSequence Analysis, DNADatabaseDysbiosisHealth statusMedDRA

Identifiers

PMID29866037
PMCPMC5987391

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.