ArticleBiological research for nursing2018
Chronic Stress in Children and Adolescents: A Review of Biomarkers for Use in Pediatric Research.
Article in Biological research for nursing, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 3 of them syntheses that pooled it.
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Who cites it
33 citing papers in PubMed, 3 syntheses or guidelines pooled it, 64 citations in OpenAlex.
- Early childhood stress responses to psychosocial stressors: The state of the science.Developmental psychobiology · 2022Pooled it
- A systematic review of the association between sleep health and stress biomarkers in children.Sleep medicine reviews · 2021Pooled it
- Pooled it
- Beyond genetics: how environmental stressors drive pediatric hypertension risk.Pediatric nephrology (Berlin, Germany) · 2026Review
- Article
- Developmental and environmental determinants of hair steroids in children from birth to two years postnatally: A comprehensive analysis.Comprehensive psychoneuroendocrinology · 2026Article
- Developing a Mindfulness Program for Families in a Pediatric Weight Management Clinic.Children (Basel, Switzerland) · 2026Article
- Elevated C-reactive protein is associated with suicide attempts in youth with bipolar disorder.Psychological medicine · 2026Article
- The Role of Sleep in Mediating Mental Health Symptoms During the COVID-19 Pandemic in Children with and Without ADHD.Children (Basel, Switzerland) · 2026Article
- Methodological trends in biological assessment of children's daily stress: A scoping review.PloS one · 2026Article
- The relationship between household economic shocks, depression, and elevated stress-responsive biomarkers among adolescent girls and young women in rural South Africa (HPTN 068).Journal of affective disorders · 2025Article
- Latent classes of adverse childhood experiences and changes in inflammation across middle age among urban-dwelling adults.Brain, behavior, and immunity · 2025Article
- Outdoor air pollution, road traffic noise, and allostatic load in children aged 6-11 years: evidence from six European cohorts.European journal of epidemiology · 2025Article
- Socioeconomic differences in adolescent health behaviors and their effect on inequalities in adult depressed mood: findings from a 27-year longitudinal study.BMC psychiatry · 2025Article
- Screen time and allostatic load among youth: findings from the National Health and Nutrition Examination Survey, 2015-2018.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2025Article
- Dietary habits and cognitive performance in primary school students: a cross-sectional study in Khemisset region in Morocco.Frontiers in nutrition · 2025Article
- The CARING study: Examining biological, behavioral, and genetic mechanisms in the intergenerational transmission of toxic stress.Research in nursing & health · 2024Article
- Reversal of Autism Symptoms among Dizygotic Twins through a Personalized Lifestyle and Environmental Modification Approach: A Case Report and Review of the Literature.Journal of personalized medicine · 2024Article
- Stress biomarkers and child development in young children in Bangladesh.Psychoneuroendocrinology · 2024Article
- Biomarkers of Stress and Inflammation in Children.Biological research for nursing · 2023Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
problemIncorporating biomarkers of chronic stress into pediatric research studies may help to explicate the links between exposure to adversity and lifelong health, but there are currently very few parameters to guide nurse researchers in choosing appropriate biomarkers of chronic stress for use in research with children and adolescents.
methodsBiomarkers of chronic stress are described, including primary mediators (glucocorticoids, catecholamines, and cytokines) and secondary outcomes (neurologic, immune, metabolic, cardiovascular, respiratory, and anthropometric) of the chronic stress response.
resultsEvidence of the use of each biomarker in pediatric research studies is reviewed. Recommendations for pediatric researchers, including selection of appropriate biomarkers, measurement considerations, potential moderators, and future directions for research, are presented. DISCUSSION: A wide range of biomarkers is available for use in research studies with children. While primary mediators of chronic stress have been frequently measured in studies of children, measurement of secondary outcomes, particularly immune and metabolic biomarkers, has been limited. With thoughtful and theoretically based approaches to selection and measurement, these biomarkers present an important opportunity to further explore the physiologic pathways linking exposure to chronic stress with later health and disease.
conclusionThe incorporation of chronic stress biomarkers into pediatric research studies may provide valuable insight into the mechanisms through which stressful environments "get under the skin" and ultimately inform efforts to promote health and reduce inequities among children exposed to adversity.
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Registered trials
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