Evidence map›Paper›PMID 29865231›Full record

ArticleNanomaterials (Basel, Switzerland)2018

Pulse-Modulated Radio-Frequency Alternating-Current-Driven Atmospheric-Pressure Glow Discharge for Continuous-Flow Synthesis of Silver Nanoparticles and Evaluation of Their Cytotoxicity toward Human Melanoma Cells.

Anna Dzimitrowicz, Aleksandra Bielawska-Pohl, George C diCenzo, Piotr Jamroz, Jan Macioszczyk, Aleksandra Klimczak, Pawel Pohl

Abstract read
In one paragraph

Article in Nanomaterials (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Plasma-Based Synthesis and Modification of Nanomaterials.Nanomaterials (Basel, Switzerland) · 2019
    Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Anna DzimitrowiczDepartment of Analytical Chemistry and Chemical Metallurgy, Faculty of Chemistry, Wroclaw University of Science and Technology, Wybrzeze St. Wyspianskiego 27, 50-370 Wroclaw, Poland. anna.dzimitrowicz@pwr.edu.pl.ORCID 0000-0003-1072-8989
Aleksandra Bielawska-PohlLaboratory of Biology of Stem and Neoplastic Cells, Hirszfeld Institute of Immunology and Experimental Therapy Polish Academy of Science, R. Weigla 12, 53-114 Wroclaw, Poland. aleksandra.bielawska@iitd.pan.wroc.pl.
George C diCenzoDepartment of Biology, University of Florence, via Madonna del Piano 6, 50017 Sesto Fiorentino, Italy. georgecolin.dicenzo@unifi.it.ORCID 0000-0003-3889-6570
Piotr JamrozDepartment of Analytical Chemistry and Chemical Metallurgy, Faculty of Chemistry, Wroclaw University of Science and Technology, Wybrzeze St. Wyspianskiego 27, 50-370 Wroclaw, Poland. piotr.jamroz@pwr.edu.pl.ORCID 0000-0003-3813-9350
Jan MacioszczykFaculty of Microsystem Electronics and Photonics, Wroclaw University of Science and Technology, Wybrzeze St. Wyspianskiego 27, 50-370 Wroclaw, Poland. jan.macioszczyk@pwr.edu.pl.
Aleksandra KlimczakLaboratory of Biology of Stem and Neoplastic Cells, Hirszfeld Institute of Immunology and Experimental Therapy Polish Academy of Science, R. Weigla 12, 53-114 Wroclaw, Poland. klimczak@iitd.pan.wroc.pl.
Pawel PohlDepartment of Analytical Chemistry and Chemical Metallurgy, Faculty of Chemistry, Wroclaw University of Science and Technology, Wybrzeze St. Wyspianskiego 27, 50-370 Wroclaw, Poland. pawel.pohl@pwr.edu.pl.ORCID 0000-0003-1844-7188

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

An innovative and environmentally friendly method for the synthesis of size-controlled silver nanoparticles (AgNPs) is presented. Pectin-stabilized AgNPs were synthesized in a plasma-reaction system in which pulse-modulated radio-frequency atmospheric-pressure glow discharge (pm-rf-APGD) was operated in contact with a flowing liquid electrode. The use of pm-rf-APGD allows for better control of the size of AgNPs and their stability and monodispersity. AgNPs synthesized under defined operating conditions exhibited average sizes of 41.62 ± 12.08 nm and 10.38 ± 4.56 nm, as determined by dynamic light scattering and transmission electron microscopy (TEM), respectively. Energy-dispersive X-ray spectroscopy (EDS) confirmed that the nanoparticles were composed of metallic Ag. Furthermore, the ξ-potential of the AgNPs was shown to be -43.11 ± 0.96 mV, which will facilitate their application in biological systems. Between 70% and 90% of the cancerous cells of the human melanoma Hs 294T cell line underwent necrosis following treatment with the synthesized AgNPs. Furthermore, optical emission spectrometry (OES) identified reactive species, such as NO, NH, N₂, O, and H, as pm-rf-APGD produced compounds that may be involved in the reduction of the Ag(I) ions.

Indexed as

cold atmospheric-pressure plasmananostructuresnecrosis

Identifiers

PMID29865231
PMCPMC6027456

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.