Evidence map›Paper›PMID 29865216›Full record

ArticleBiomolecules2018

Redesigning TOR Kinase to Explore the Structural Basis for TORC1 and TORC2 Assembly.

Andrew Hill, Brad Niles, Andrew Cuyegkeng, Ted Powers

Abstract read
In one paragraph

Article in Biomolecules, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. SARS-CoV-2 Molecular Network Structure.Frontiers in physiology · 2020
    Article
  7. Analysis of the roles of phosphatidylinositol-4,5-Molecular biology of the cell · 2019
    Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Andrew HillDepartment of Molecular and Cellular Biology, College of Biological Sciences, University of California Davis, Davis, CA 95616, USA. awhill@ucdavis.edu.
Brad NilesDepartment of Molecular and Cellular Biology, College of Biological Sciences, University of California Davis, Davis, CA 95616, USA. bjniles@ucdavis.edu.
Andrew CuyegkengDepartment of Molecular and Cellular Biology, College of Biological Sciences, University of California Davis, Davis, CA 95616, USA. ajcuyegkeng@ucdavis.edu.
Ted PowersDepartment of Molecular and Cellular Biology, College of Biological Sciences, University of California Davis, Davis, CA 95616, USA. tpowers@ucdavis.edu.ORCID 0000-0002-2007-3819

Funding

TOR Complex 2 and sphingolipid biosynthesis.R01GM086387 · NIGMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI POWERS, TED · 2009 to 2012
$1.3M
NIGMS NIH HHS R01 GM086387
6 · The paper itself

Abstract

TOR is a serine/threonine protein kinase that assembles into distinct TOR Complexes 1 and 2 (TORC1 or TORC2) to regulate cell growth. In mammalian cells, a single mTOR incorporates stably into mTORC1 and mTORC2. By contrast, in

Indexed as

Protein MultimerizationCell Cycle ProteinsMechanistic Target of Rapamycin Complex 1Mechanistic Target of Rapamycin Complex 2Phosphatidylinositol 3-KinasesProtein BindingProtein DomainsSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsCell Cycle ProteinsMechanistic Target of Rapamycin Complex 1Mechanistic Target of Rapamycin Complex 2Phosphatidylinositol 3-KinasesSaccharomyces cerevisiae ProteinsTOR1 protein, S cerevisiaeTOR2 protein, S cerevisiaeAGC kinasesHEAT repeatsmTOR pathwayrapamycin

Identifiers

PMID29865216
PMCPMC6023025

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.