Evidence map›Paper›PMID 29865182›Full record

ArticleToxins2018

The Binary Toxin CDT of

Lara-Antonia Beer, Helma Tatge, Carmen Schneider, Maximilian Ruschig, Michael Hust, Jessica Barton, Stefan Thiemann, Viola Fühner, Giulio Russo, Ralf Gerhard

Open access · goldAbstract read
In one paragraph

Article in Toxins, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Gut microbes · 2025
    Article
  3. Review
  4. Review
  5. Article
  6. Targeting the Inside of Cells with Biologicals: Toxin Routes in a Therapeutic Context.BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy · 2023
    Review
  7. CDT ofToxins · 2023
    Article
  8. TcdB ofInternational journal of molecular sciences · 2022
    Article
  9. Article
  10. The Importance of Therapeutically Targeting the Binary Toxin fromInternational journal of molecular sciences · 2021
    Review
  11. Frontiers in microbiology · 2021
    Article
  12. The Binary Toxin ofFrontiers in microbiology · 2021
    Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Lara-Antonia BeerInstitute of Toxicology, Hannover Medical School, 30625 Hannover, Germany. beer.lara-antonia@mh-hannover.de.
Helma TatgeInstitute of Toxicology, Hannover Medical School, 30625 Hannover, Germany. tatge.helma@mh-hannover.de.
Carmen SchneiderInstitute of Toxicology, Hannover Medical School, 30625 Hannover, Germany. schneider.carmen@mh-hannover.de.
Maximilian RuschigDepartment of Biochemistry and Biotechnology, Technical University Braunschweig, 38106 Braunschweig, Germany. m.ruschig@tu-braunschweig.de.
Michael HustDepartment of Biochemistry and Biotechnology, Technical University Braunschweig, 38106 Braunschweig, Germany. m.hust@tu-braunschweig.de.
Jessica BartonInstitute of Toxicology, Hannover Medical School, 30625 Hannover, Germany. barton.jessica@mh-hannover.de.
Stefan ThiemannInstitute of Toxicology, Hannover Medical School, 30625 Hannover, Germany. thiemann.stefan@mh-hannover.de.
Viola FühnerDepartment of Biochemistry and Biotechnology, Technical University Braunschweig, 38106 Braunschweig, Germany. v.fuehner@tu-braunschweig.de.
Giulio RussoDepartment of Biochemistry and Biotechnology, Technical University Braunschweig, 38106 Braunschweig, Germany. g.russo@tu-braunschweig.de.ORCID 0000-0003-4099-6968
Ralf GerhardInstitute of Toxicology, Hannover Medical School, 30625 Hannover, Germany. gerhard.ralf@mh-hannover.de.
Medizinische Hochschule Hannover · DETechnische Universität Braunschweig · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Binary toxins are produced by several pathogenic bacteria. Examples are the C2 toxin from

Indexed as

ADP Ribose TransferasesBacterial ProteinsBiological TransportCell Line, TumorCytosolDrug Delivery SystemsGlucosyltransferasesHumansProtein DomainsRecombinant Fusion Proteinsactin-specific ADP-ribosyltransferase, ClostridiumADP Ribose TransferasesBacterial ProteinsGlucosyltransferasesRecombinant Fusion ProteinsADP-ribosyltransferasebinary toxinsClostridium difficileglucosyltransferaseprotein delivery

Identifiers

PMID29865182
PMCPMC6024811
OpenAlexW2806770330

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.