Evidence map›Paper›PMID 29865067›Full record

ArticleJournal of Alzheimer's disease : JAD2018

Time Trends in the Prevalence of Neurocognitive Disorders and Cognitive Impairment in the United States: The Effects of Disease Severity and Improved Ascertainment.

Igor Akushevich, Arseniy P Yashkin, Julia Kravchenko, Svetlana Ukraintseva, Eric Stallard, Anatoliy I Yashin

Open access · greenAbstract read
In one paragraph

Article in Journal of Alzheimer's disease : JAD, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
  2. Observational
  3. Article
  4. Article
  5. Risk of Alzheimer's disease and related dementia by sex and race/ethnicity: The Multiethnic Cohort Study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2022
    Article
  6. Article
  7. Validation of Claims Algorithms to Identify Alzheimer's Disease and Related Dementias.The journals of gerontology. Series A, Biological sciences and medical sciences · 2022
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Using Medicare claims in identifying Alzheimer's disease and related dementias.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2020
    Article
  16. Dual-Task Gait Assessment and Machine Learning for Early-detection of Cognitive Decline.Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · 2020
    Article
  17. The Alzheimer's Disease Exposome.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2019
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Igor AkushevichBiodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham, NC, USA.
Arseniy P YashkinBiodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham, NC, USA.
Julia KravchenkoDepartment of Surgery, Duke University Medical Center, Durham, NC, USA.
Svetlana UkraintsevaBiodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham, NC, USA.
Eric StallardBiodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham, NC, USA.
Anatoliy I YashinBiodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham, NC, USA.
Social Science Research Council · USDuke University · USDuke Medical Center · US

Funding

Relationships among Genetic Regulators of Aging Health and LifespanP01AG043352 · NIA · DUKE UNIVERSITY · PI YASHIN, ANATOLIY I · 2014 to 2018
$8.7M
YASHIN Admin Supp: Time Trends in Alzheimer's Disease: Addressing the Changing Role of Risk Factors and Instrument ValidityR01AG046860 · NIA · DUKE UNIVERSITY · PI YASHIN, ANATOLIY I · 2014 to 2018
$3.1M
Genetic Modulations of Morbidity Compression: A Population-Based StudyR56AG047402 · NIA · DUKE UNIVERSITY · PI STALLARD, P.J. ERIC · 2016 to 2016
$793k
NIA NIH HHS P01 AG043352NIA NIH HHS R01 AG046860NIA NIH HHS R56 AG047402
6 · The paper itself

Abstract

backgroundTrends in the prevalence of cognitive impairment (CI) based on cognitive assessment instruments are often inconsistent with those of neurocognitive disorders (ND) based on Medicare claims records.

objectiveWe hypothesized that improved ascertainment and resulting decrease in disease severity at the time of diagnosis are responsible for this phenomenon.

methodsUsing Medicare data linked to the Health and Retirement Study (1992-2012), we performed a joint analysis of trends in CI and ND to test our hypothesis.

resultsWe identified two major contributors to the divergent directions in CI and ND trends: reductions in disease severity explained more than 60% of the differences between CI and ND prevalence over the study period; the remaining 40% was explained by a decrease in the fraction of undiagnosed individuals. DISCUSSION: Improvements in the diagnoses of ND diseases were a major contributor to reported trends in ND and CI. Recent forecasts of CI and ND trends in the U.S. may be overly pessimistic.

Indexed as

AgedAged, 80 and overAge FactorsCognitive DysfunctionFemaleHumansLongitudinal StudiesMaleNeurocognitive DisordersNeuropsychological TestsPrevalenceRetirementUnited StatesAlzheimer’s diseaseAscertainmentcognitive impairmentdisease prevalenceHealth and Retirement Study (HRS)Medicareneurocognitive disordersseverityTelephone Interview for Cognitive Status (TICS)time trendsunderdiagnosis

Identifiers

PMID29865067
PMCPMC6214183
OpenAlexW2806295519

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.