Evidence map›Paper›PMID 29864474›Full record

ArticleJournal of controlled release : official journal of the Controlled Release Society2018

Focused ultrasound-enabled delivery of radiolabeled nanoclusters to the pons.

Dezhuang Ye, Deborah Sultan, Xiaohui Zhang, Yimei Yue, Gyu Seong Heo, Satya V V N Kothapalli, Hannah Luehmann, Yuan-Chuan Tai, Joshua B Rubin, Yongjian Liu and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of controlled release : official journal of the Controlled Release Society, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 60 citations in OpenAlex.

  1. Review
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  5. Targeting diffuse midline gliomas: The promise of focused ultrasound-mediated blood-brain barrier opening.Journal of controlled release : official journal of the Controlled Release Society · 2024
    Review
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  12. Focused Ultrasound-Mediated Intranasal Brain Drug Delivery Technique (FUSIN).Methods in molecular biology (Clifton, N.J.) · 2022
    Article
  13. A review of bioeffects induced by focused ultrasound combined with microbubbles on the neurovascular unit.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Dezhuang YeDepartment of Mechanical Engineering and Material Science, Washington University in St. Louis, Saint Louis, MO 63130, USA.
Deborah SultanMallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Xiaohui ZhangMallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Yimei YueDepartment of Biomedical Engineering, Washington University in St. Louis, Saint Louis, MO 63130, USA.
Gyu Seong HeoMallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Satya V V N KothapalliDepartment of Biomedical Engineering, Washington University in St. Louis, Saint Louis, MO 63130, USA.
Hannah LuehmannMallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Yuan-Chuan TaiMallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Joshua B RubinDepartment of Pediatrics, Department of Neuroscience, Washington University School of Medicine, St. Louis, MO 63110, USA.
Yongjian LiuMallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO 63110, USA. Electronic address: yongjianliu@wustl.edu.
Hong ChenDepartment of Biomedical Engineering, Washington University in St. Louis, Saint Louis, MO 63130, USA; Department of Radiation Oncology, Washington University School of Medicine, Saint Louis, MO 63108, USA. Electronic address: hongchen@wustl.edu.
Mallinckrodt (United States) · USWashington University in St. Louis · US

Funding

Project 2 - Radiation-Induced Treatment of Multiple Myeloma using NanoparticlesU54CA199092 · NCI · WASHINGTON UNIVERSITY · PI ACHILEFU, SAMUEL · 2015 to 2019
$11.5M
Image-guided focused ultrasound-mediated intranasal brain drug delivery technique (FUSIN)R01EB027223 · NIBIB · WASHINGTON UNIVERSITY · PI Hong Chen · 2019 to 2026
$4.3M
FOCUS: FUNCTIONAL OPTICAL IMAGING FEEDBACK-CONTROLLED CELLULAR-LEVEL ULTRASOUND STIMULATIONR01MH116981 · NIMH · WASHINGTON UNIVERSITY · PI CHEN, HONG · 2018 to 2021
$2.8M
NCI NIH HHS U54 CA199092NIBIB NIH HHS R01 EB027223NIMH NIH HHS R01 MH116981
6 · The paper itself

Abstract

The goal of this study was to establish the feasibility of integrating focused ultrasound (FUS)-mediated delivery of

Indexed as

Ultrasonic WavesAnimalsBrainCopper RadioisotopesGoldMaleMice, Inbred C57BLMicrobubblesNanostructuresPositron Emission Tomography Computed TomographyCopper RadioisotopesGoldBlood-brain barrierBrainDrug deliveryFocused ultrasoundImage-guided drug deliveryNanoclustersPonsPositron emission tomography

Identifiers

PMID29864474
PMCPMC6035767
OpenAlexW2805332746

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.