ArticleAmerican journal of respiratory and critical care medicine2018
A Disintegrin and Metalloproteinase Domain-9: A Novel Proteinase Culprit with Multifarious Contributions to Chronic Obstructive Pulmonary Disease.
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Article in American journal of respiratory and critical care medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 37 citations in OpenAlex.
- Matrix Metalloproteinase-8 Deficiency Alters the Balance Between Viral Clearance and Immunopathology in H1N1 Infection.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Article
- Extracellular Vesicles Released by Picornavirus-Infected Cells Modify Antiviral Immune Cell Responses.Journal of extracellular vesicles · 2026Article
- M2 Macrophage membrane-mediated biomimetic nanoparticles carrying ADAM9 siRNA alleviate renal inflammation and fibrosis via the AKT/NF-κB pathway.Journal of nanobiotechnology · 2026Article
- An Integrative Proteotranscriptomics Approach Reveals New ADAM9 Substrates and Downstream Pathways.Molecular & cellular proteomics : MCP · 2026Article
- Perturbation of EPHA2 and EFNA1iScience · 2025Article
- Hypoxia Promotes the Expression of ADAM9 by Tubular Epithelial Cells, Which Enhances Transforming Growth Factor β1 Activation and Promotes Tissue Fibrosis in Patients With Lupus Nephritis.Arthritis & rheumatology (Hoboken, N.J.) · 2025Article
- Developmental immune network of airway lymphocytes and innate immune cells in patients with stable COPD.Frontiers in immunology · 2025Article
- Advances on the Role of Lung Macrophages in the Pathogenesis of Chronic Obstructive Pulmonary Disease in the Era of Single-Cell Genomics.International journal of medical sciences · 2025Review
- Microglia-derived ADAM9 promote GHRH neurons pyroptosis by Mad2L2-JNK-caspase-1 pathway in subarachnoid hemorrhage.Journal of neuroinflammation · 2024Article
- Diagnostic Challenges and Pathogenetic Differences in Biomass-Smoke-Induced versus Tobacco-Smoke-Induced COPD: A Comparative Review.Diagnostics (Basel, Switzerland) · 2024Review
- Glycosylated, Lipid-Binding, CDR-Like Domains of SARS-CoV-2 ORF8 Indicate Unique Sites of Immune Regulation.Microbiology spectrum · 2023Article
- Extracellular vesicle-encapsulated CC16 as novel nanotherapeutics for treatment of acute lung injury.Molecular therapy : the journal of the American Society of Gene Therapy · 2023Article
- Characterization of pulmonary vascular remodeling and MicroRNA-126-targets in COPD-pulmonary hypertension.Respiratory research · 2022Article
- Exosomes derived from adipose-derived stem cells alleviate cigarette smoke-induced lung inflammation and injury by inhibiting alveolar macrophages pyroptosis.Respiratory research · 2022Article
- IL-17A Promotes Epithelial ADAM9 Expression in Cigarette Smoke-Related COPD.International journal of chronic obstructive pulmonary disease · 2022Article
- Basement membranes in obstructive pulmonary diseases.Matrix biology plus · 2021Review
- Overexpression of ADAM9 decreases radiosensitivity of hepatocellular carcinoma cell by activating autophagy.Bioengineered · 2021Article
- An Overview of ADAM9: Structure, Activation, and Regulation in Human Diseases.International journal of molecular sciences · 2020Review
- ADAM15 expression is increased in lung CD8Respiratory research · 2020Article
- COVID-19, COPD, and AECOPD: Immunological, Epidemiological, and Clinical Aspects.Frontiers in medicine · 2020Review
Corrections and comments
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Authors and funding
18 authors at 5 institutions in 4 countries.
Xiaoyun WangDivision of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.ORCID 0000-0002-9900-740X
Francesca PolverinoDivision of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.ORCID 0000-0001-9686-5698
Joselyn Rojas-QuinteroDivision of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.ORCID 0000-0003-4994-075X
Duo ZhangPulmonary Center, Boston University School of Medicine, Boston, Massachusetts.
José SánchezQuantitative Biology, Discovery Sciences.
Ilyas YambayevDivision of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
Eva LindqvistStudy Enterprise, Early Clinical Development at Innovative Medicines and Early Development Biotech Unit, AstraZeneca, Gothenburg, Sweden.
Robert VirtalaEpithelium, Respiratory, Inflammation and Autoimmunity at Innovative Medicines and Early Development Biotech Unit, AstraZeneca Research & Development, Gothenburg, Sweden.
Ratko DjukanovicNational Institute for Health Research Southampton, Respiratory Biomedical Research Centre and Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.
Donna E DaviesNational Institute for Health Research Southampton, Respiratory Biomedical Research Centre and Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.
Susan WilsonHistochemistry Research Unit, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.
Rory O'DonnellSt. James's Hospital, Dublin, Ireland; and.
Danen CunoosamyEpithelium, Respiratory, Inflammation and Autoimmunity at Innovative Medicines and Early Development Biotech Unit, AstraZeneca Research & Development, Gothenburg, Sweden.
Petra HazonEpithelium, Respiratory, Inflammation and Autoimmunity at Innovative Medicines and Early Development Biotech Unit, AstraZeneca Research & Development, Gothenburg, Sweden.
Andrew HighamMedicines Evaluation Unit, University of Manchester, Manchester University National Health Service Foundation Trust, Manchester, United Kingdom.
Dave SinghMedicines Evaluation Unit, University of Manchester, Manchester University National Health Service Foundation Trust, Manchester, United Kingdom.
Henric OlssonEpithelium, Respiratory, Inflammation and Autoimmunity at Innovative Medicines and Early Development Biotech Unit, AstraZeneca Research & Development, Gothenburg, Sweden.
Caroline A OwenDivision of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.ORCID 0000-0003-4377-3591
Brigham and Women's Hospital · USNational Health Service · GBNational Institute for Health Research · GBBoston University · USQuantitative BioSciences · US
Funding
Respiratory Computational Discovery CoreP01HL114501 · NHLBI · WEILL MEDICAL COLL OF CORNELL UNIV · PI CHOI, MARY E · 2013 to 2025
$24.9MSystems Biology, Bioinformatics, and BiostatisticsP01HL105339 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SILVERMAN, EDWIN K · 2011 to 2015
$12.2MTargeting MMP9 to Improve Outcomes in Serious Influenza InfectionsR01AI111475 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI HARROD, KEVIN S, LEVY, BRUCE D · 2014 to 2018
$4.3MNovel Roles for MMP-8 in Acute Lung InjuryR01HL063137 · NHLBI · UNIVERSITY OF UTAH · PI OWEN, CAROLINE A · 1999 to 2008
$2.6MNovel Roles for ADAM15 in Acute Lung InjuryR01HL086814 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI OWEN, CAROLINE A · 2007 to 2010
$1.6MNovel Anti-inflammatory Activities For ADAM8 In Pulmonary EmphysemaR21HL111835 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI OWEN, CAROLINE A · 2012 to 2013
$456kNHLBI NIH HHS P01 HL105339NHLBI NIH HHS P01 HL114501NHLBI NIH HHS R01 HL063137NHLBI NIH HHS R01 HL086814NHLBI NIH HHS R21 HL111835NIAID NIH HHS R01 AI111475
Abstract
PubMed holds no abstract for this paper.
Indexed as
emphysemagrowth factor receptorinflammationmucus metaplasiasmall-airway fibrosis
Identifiers
What OpenQuestion holds
Textmetadata
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Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.