ArticlePLoS neglected tropical diseases2018
Molecular characterization of Vibrio cholerae responsible for cholera epidemics in Uganda by PCR, MLVA and WGS.
Article in PLoS neglected tropical diseases, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Genomic epidemiology reveals geographically structured co-circulation of AFR10 and AFR13Microbial genomics · 2026Article
- Household vulnerability to climate impacts on WASH and risk mitigation in informal settlements of Eastern Uganda.Scientific reports · 2026Article
- Multicountry genomic analysis underscores regional cholera spread in Africa.Nature communications · 2026Article
- Genomic characterization of multidrug-resistant extended-spectrum β-lactamase-producing Vibrio cholerae O1 strains from 2022 cholera outbreak in Kenya.The Journal of antimicrobial chemotherapy · 2025Article
- Whole genome sequencing and transmission analysis ofmedRxiv : the preprint server for health sciences · 2025Article
- Continued T12 transmission and shared antibiotic resistance during 2018-2023 Vibrio cholerae outbreaks in Cameroon.PLOS global public health · 2025Article
- Genomic evolution and rearrangement of CTX-Φ prophage elements inEmerging microbes & infections · 2024Article
- Genomic evidence of two-staged transmission of the early seventh cholera pandemic.Nature communications · 2024Article
- Genomic insights into the 2022-2023Vibrio cholerae outbreak in Malawi.Nature communications · 2024Article
- Genomic epidemiology reveals multidrug resistant plasmid spread between Vibrio cholerae lineages in Yemen.Nature microbiology · 2023Article
- Article
- Whole Genome Sequencing Contributions and Challenges in Disease Reduction Focused on Malaria.Biology · 2022Review
- Cholera epidemic amidst the COVID-19 pandemic in Moroto district, Uganda: Hurdles and opportunities for control.PLOS global public health · 2022Article
- Contrasting Epidemiology of Cholera in Bangladesh and Africa.The Journal of infectious diseases · 2021Review
- Article
- Three transmission events of Vibrio cholerae O1 into Lusaka, Zambia.BMC infectious diseases · 2021Article
- Cholera Hot-Spots and Contextual Factors in Burundi, Planning for Elimination.Tropical medicine and infectious disease · 2021Article
- Successive epidemic waves of cholera in South Sudan between 2014 and 2017: a descriptive epidemiological study.The Lancet. Planetary health · 2020Article
- A Vibrio cholerae Core Genome Multilocus Sequence Typing Scheme To Facilitate the Epidemiological Study of Cholera.Journal of bacteriology · 2020Article
- A prolonged cholera outbreak caused by drinking contaminated stream water, Kyangwali refugee settlement, Hoima District, Western Uganda: 2018.Infectious diseases of poverty · 2020Article
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10 authors.
Funding
Abstract
backgroundFor almost 50 years sub-Saharan Africa, including Uganda, has experienced several outbreaks due to Vibrio cholerae. Our aim was to determine the genetic relatedness and spread of strains responsible for cholera outbreaks in Uganda. METHODOLOGY/PRINCIPAL
findingsSixty-three V. cholerae isolates collected from outbreaks in Uganda between 2014 and 2016 were tested using multiplex polymerase chain reaction (PCR), multi-locus variable number of tandem repeat analysis (MLVA) and whole genome sequencing (WGS). Three closely related MLVA clonal complexes (CC) were identified: CC1, 32% (20/63); CC2, 40% (25/63) and CC3, 28% (18/63). Each CC contained isolates from a different WGS clade. These clades were contained in the third wave of the 7th cholera pandemic strain, two clades were contained in the transmission event (T)10 lineage and other in T13. Analysing the dates and genetic relatedness revealed that V. cholerae genetic lineages spread between districts within Uganda and across national borders.
conclusionThe V. cholerae strains showed local and regional transmission within Uganda and the East African region. To prevent, control and eliminate cholera, these countries should implement strong cross-border collaboration and regional coordination of preventive activities.
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