ArticleJournal of clinical gastroenterology2019
Pancreas Divisum in Pediatric Acute Recurrent and Chronic Pancreatitis: Report From INSPPIRE.
Article in Journal of clinical gastroenterology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03672422 (Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer), which is not on this map. Cited by 23 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer (CPDPC) CPDPC16-03 Pediatric Longitudinal Cohort Study of Chronic Pancreatitis
Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 49 citations in OpenAlex.
- The Prevalence of Pancreas Divisum and Its Association with Pancreatic Diseases: A Systematic Review and Meta-Analysis.Medicina (Kaunas, Lithuania) · 2026Pooled it
- Stent placement in pancreatic disease, when, which and why? - a current perspective.Frontiers in gastroenterology (Lausanne, Switzerland) · 2022Pooled it
- Acute pancreatitis associated with Mycoplasma pneumoniae infection in a child with incomplete pancreas divisum.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026Article
- The Role of Endoscopic Ultrasound in the Diagnosis and Management of Congenital Gastrointestinal and Pancreaticobiliary Conditions.Current gastroenterology reports · 2026Review
- Progression from acute to chronic pancreatitis in children: a systematic review and meta-analysis.Clinical and experimental pediatrics · 2026Article
- Genetic Investigations in Turkish Idiopathic Pancreatitis Patients Show Unique Characteristics.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2023Article
- Endoscopic Ultrasound in Pancreatic Duct Anomalies.Diagnostics (Basel, Switzerland) · 2023Review
- A possible manifestation of pancreas divisum-pancreatic pseudocyst in an infant with no apparent history of pancreatitis: a case report.Surgical case reports · 2023Article
- Long-Term Follow-Up and Outcome of Pediatric Acute Pancreatitis: A Multicenter Study.Turkish archives of pediatrics · 2023Article
- Endoscopic Advancements in Pediatric Pancreatitis.Frontiers in pediatrics · 2022Article
- Risk factors for the progression from acute recurrent to chronic pancreatitis among children in China.Frontiers in pediatrics · 2022Article
- Current State of Imaging of Pediatric Pancreatitis:AJR. American journal of roentgenology · 2021Review
- Analysis of the Efficacy and Safety of Endoscopic Retrograde Cholangiopancreatography in Children With Symptomatic Pancreas Divisum.Frontiers in pediatrics · 2021Article
- Genetic Evaluation of Children with Idiopathic Recurrent Acute Pancreatitis.Digestive diseases and sciences · 2020Article
- Clinical and Practice Variations in Pediatric Acute Recurrent or Chronic Pancreatitis: Report From the INSPPIRE Study.Journal of pediatric gastroenterology and nutrition · 2020Article
- Identification and management of pancreas divisum.Expert review of gastroenterology & hepatology · 2019Review
- Diabetes Mellitus in Children with Acute Recurrent and Chronic Pancreatitis: Data From the INternational Study Group of Pediatric Pancreatitis: In Search for a CuRE Cohort.Journal of pediatric gastroenterology and nutrition · 2019Article
- Pancreatitis in Children.Gastroenterology · 2019Review
- Endoscopic and Conservative Management of Chronic Pancreatitis and Its Complications.Visceral medicine · 2019Review
- Chronic Pancreatitis: Pediatric and Adult Cohorts Show Similarities in Disease Progress Despite Different Risk Factors.Journal of pediatric gastroenterology and nutrition · 2019Article
Corrections and comments
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Authors and funding
31 authors at 13 institutions in 3 countries.
Funding
Abstract
introductionThe significance of pancreas divisum (PD) as a risk factor for pancreatitis is controversial. We analyzed the characteristics of children with PD associated with acute recurrent or chronic pancreatitis to better understand its impact. PATIENTS AND
methodsWe compared children with or without PD in the well-phenotyped INSPPIRE (INternational Study group of Pediatric Pancreatitis: In search for a cuRE) cohort. Differences were analyzed using 2-sample t test or Wilcoxon rank sum test for continuous variables, Pearson χ or Fisher exact test for categorical variables.
resultsPD was found in 52 of 359 (14.5%) subjects, a higher prevalence than the general population (∼7%). Females more commonly had PD (71% vs. 55%; P=0.02). Children with PD did not have a higher incidence of mutations in SPINK1, CFTR, CTRC compared with children with no PD. Children with PD were less likely to have PRSS1 mutations (10% vs. 34%; P<0.01) or a family history of pancreatitis (P<0.05), and more likely to have hypertriglyceridemia (11% vs. 3%; P=0.03). Children with PD underwent significantly more endoscopic procedures and pancreatic sphincterotomy. Patients with PD had fewer attacks of acute pancreatitis (P=0.03) and were less likely to develop exocrine pancreatic insufficiency (P=0.01). Therapeutic endoscopic retrograde cholangiopancreatography was considered most helpful if pancreatic duct was impacted with stones (83% helpful).
conclusionsPD is likely a risk factor for acute recurrent pancreatitis and chronic pancreatitis in children that appears to act independently of genetic risk factors. Patients with PD and stones obstructing the pancreatic duct benefit most from therapeutic endoscopic retrograde cholangiopancreatography.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.