Evidence map›Paper›PMID 29863793›Full record

ArticleNMR in biomedicine2019

Ex vivo diffusion MRI of the human brain: Technical challenges and recent advances.

Alard Roebroeck, Karla L Miller, Manisha Aggarwal

Abstract read
In one paragraph

Article in NMR in biomedicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 80 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
80citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

80 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Guideline
  2. Pooled it
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  10. Review
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  17. Imaging of developing human brains with ex vivo PSOCT and dMRI.Imaging neuroscience (Cambridge, Mass.) · 2025
    Article
  18. Article
  19. Review
  20. Article

20 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Alard RoebroeckDepartment of Cognitive Neuroscience, Faculty of Psychology & Neuroscience, Maastricht University, Maastricht, the Netherlands.ORCID 0000-0003-0895-1145
Karla L MillerFMRIB Centre, University of Oxford, Oxford, UK.
Manisha AggarwalDepartment of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Funding

Imaging platform and computational HARDI atlas of the human hippocampusR01AG057991 · NIA · JOHNS HOPKINS UNIVERSITY · PI AGGARWAL, MANISHA · 2018 to 2022
$1.8M
Oscillating gradient diffusion MRI and quantitative susceptibility mapping in the epileptogenic brainR21NS096249 · NINDS · JOHNS HOPKINS UNIVERSITY · PI AGGARWAL, MANISHA · 2016 to 2017
$430k
Multi-resolution three dimensional stereotaxic atlas of the human brainstemR03EB017806 · NIBIB · JOHNS HOPKINS UNIVERSITY · PI AGGARWAL, MANISHA · 2014 to 2015
$162k
Dutch Science Foundation (NWO) VIDI Grant (#14637)European Research Council ERC Starting Grant (MULTICONNECT, #639938)NIA NIH HHS R01 AG057991NIBIB NIH HHS R03 EB017806NIH HHS R03EB017806R21NS096249NINDS NIH HHS R21 NS096249Wellcome Trust 202788/Z/16/Z
6 · The paper itself

Abstract

This review discusses ex vivo diffusion magnetic resonance imaging (dMRI) as an important research tool for neuroanatomical investigations and the validation of in vivo dMRI techniques, with a focus on the human brain. We review the challenges posed by the properties of post-mortem tissue, and discuss state-of-the-art tissue preparation methods and recent advances in pulse sequences and acquisition techniques to tackle these. We then review recent ex vivo dMRI studies of the human brain, highlighting the validation of white matter orientation estimates and the atlasing and mapping of large subcortical structures. We also give particular emphasis to the delineation of layered gray matter structure with ex vivo dMRI, as this application illustrates the strength of its mesoscale resolution over large fields of view. We end with a discussion and outlook on future and potential directions of the field.

Indexed as

Diffusion Magnetic Resonance ImagingBrainDiffusion Tensor ImagingGray MatterHumansVisual Cortexcortical layersdiffusion MRIex vivogray mattervalidationwhite matter

Identifiers

PMID29863793
PMCPMC6492287

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.