Evidence map›Paper›PMID 29863787›Full record

ArticleImmunology and cell biology2018

Regulation of B-lineage cells by caspase 6.

Chie Watanabe, Geraldine L Shu, Natalia V Giltiay, Edward A Clark

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Immunology and cell biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.1field-weighted citation impact, top 55% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Exploring caspase functions in mouse models.Apoptosis : an international journal on programmed cell death · 2024
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Chie WatanabeDepartment of Immunology, University of Washington, Seattle, WA, 98109, USA.
Geraldine L ShuDepartment of Immunology, University of Washington, Seattle, WA, 98109, USA.
Natalia V GiltiayDepartment of Immunology, University of Washington, Seattle, WA, 98109, USA.
Edward A ClarkDepartment of Immunology, University of Washington, Seattle, WA, 98109, USA.
University of Washington · US

Funding

Programming protective immunity by targeting antigens to the CD180 receptorR01AI052203 · NIAID · UNIVERSITY OF WASHINGTON · PI FULLER, DEBORAH H. · 2003 to 2019
$6.3M
FDRC1 AND FOLLICULAR DENDRITIC CELL SIGNALING PATHWAYSR37AI044257 · NIAID · UNIVERSITY OF WASHINGTON · PI CLARK, EDWARD A · 2004 to 2013
$4.0M
Role of B cell activating factor (BAFF) in B cell responses and autoimmunityR01AI044257 · NIAID · UNIVERSITY OF WASHINGTON · PI GILTIAY, NATALIA V · 1999 to 2020
$3.7M
STRUCTURE/FUNCTION HUMAN B CELL DIFFERENTIATION ANTIGENSR01GM037905 · NIGMS · UNIVERSITY OF WASHINGTON · PI CLARK, EDWARD A · 1987 to 2007
$2.4M
NIAID NIH HHS R01 AI044257NIAID NIH HHS R01 AI052203NIAID NIH HHS R37 AI044257NIGMS NIH HHS R01 GM037905
6 · The paper itself

Abstract

The caspase (Casp) family of proteases regulate both lymphocyte apoptosis and activation. Here, we show that Casp6 regulates early B-cell development. One-week-old Casp6 knockout (Casp6 KO) mice have significantly more splenic B-cell subsets than wild-type (WT) mice. Adult Casp6 KO mice have normal levels of total splenic B cells but have increased numbers of B1a B cells and CD43

Indexed as

ImmunomodulationAnimalsAnimals, NewbornB-LymphocytesCaspase 6Interleukin-7Lymphoid Progenitor CellsLymphopoiesisMaleMiceMice, KnockoutPeyer's PatchesSpleenCaspase 6Interleukin-7B cellsbone marrowcaspaselymphopoiesisspleen

Identifiers

PMID29863787
PMCPMC6814014
OpenAlexW2805865471

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.