Evidence map›Paper›PMID 29863531›Full record

ArticleEpidemiology (Cambridge, Mass.)2018

Exposures to Air Pollution and Risk of Acute-onset Placental Abruption: A Case-crossover Study.

Cande V Ananth, Marianthi-Anna Kioumourtzoglou, Yongmei Huang, Zev Ross, Alexander M Friedman, Michelle A Williams, Shuang Wang, Murray A Mittleman, Joel Schwartz

Abstract read
In one paragraph

Article in Epidemiology (Cambridge, Mass.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Maternal PMReproductive toxicology (Elmsford, N.Y.) · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Air pollution and pregnancy.Seminars in perinatology · 2023
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Maternal Exposure to Ambient Air Pollution and Pregnancy Complications in Victoria, Australia.International journal of environmental research and public health · 2020
    Article
  17. Article
  18. Ambient PMInhalation toxicology
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Cande V AnanthFrom the Department of Obstetrics and Gynecology, College of Physicians and Surgeons, Columbia University, New York, NY.
Marianthi-Anna KioumourtzoglouDepartment of Environmental Health Sciences, Joseph L. Mailman School of Public Health, Columbia University, New York, NY.
Yongmei HuangFrom the Department of Obstetrics and Gynecology, College of Physicians and Surgeons, Columbia University, New York, NY.
Zev RossZevRoss Spatial Analysis, Ithaca, NY.
Alexander M FriedmanFrom the Department of Obstetrics and Gynecology, College of Physicians and Surgeons, Columbia University, New York, NY.
Michelle A WilliamsDepartment of Epidemiology, Harvard TH Chan School of Public Health, Boston, MA.
Shuang WangDepartment of Biostatistics, Joseph L. Mailman School of Public Health, Columbia University, New York, NY.
Murray A MittlemanDepartment of Epidemiology, Harvard TH Chan School of Public Health, Boston, MA.
Joel SchwartzDepartment of Epidemiology, Harvard TH Chan School of Public Health, Boston, MA.

Funding

True Metal fac coreP30ES009089 · NIEHS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MATTHEW S PERZANOWSKI · 1998 to 2026
$44.7M
Mentored Clinical Scientist Research Career Development AwardK08HD082287 · NICHD · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI FRIEDMAN, ALEXANDER M · 2015 to 2018
$593k
Air Pollution and Risk of Placental Abruption in New York CityR21ES025845 · NIEHS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI WAPNER, RONALD · 2015 to 2016
$440k
NICHD NIH HHS K08 HD082287NIEHS NIH HHS P30 ES009089NIEHS NIH HHS R21 ES025845
6 · The paper itself

Abstract

backgroundDespite abruption's elusive etiology, knowledge of triggers that precede it by just a few days prior to delivery may help to understand the underpinnings of this acute obstetrical complication. We examine whether air pollution exposures immediately preceding delivery are associated with acute-onset abruptions.

methodsWe applied a bidirectional, time-stratified, case-crossover design to births with an abruption diagnosis in New York City, 2008-2014. We measured ambient fine particulate matter (PM2.5) and nitrogen dioxide (NO2). We fit distributed lag nonlinear models based on conditional logistic regression to evaluate individual exposure and cumulative exposures over lags 0-7 days before abruption, adjusted for temperature and relative humidity (similar lags to the main exposures).

resultsWe identified 1,190 abruption cases. We observed increased odds of abruption for exposure to PM2.5 (per 10 μg/m) on lag day 3 (odds ratio [OR] 1.19, 95% confidence interval [CI] = 0.98, 1.43), lag day 4 (OR 1.21, 95% CI = 1.01, 1.46), and lag day 5 (OR 1.17, 95% CI = 1.03, 1.33). Similarly, the odds of abruption increased with exposure to NO2 (per 5 ppb) on lag day 3 (OR 1.16, 95% CI = 0.98, 1.37), lag day 4 (OR 1.19, 95% CI = 1.02, 1.39), and lag day 5 (OR 1.16, 95% CI = 1.05, 1.27). Exposures to PM2.5 and NO2 at other lags, or cumulative exposures, were not associated with abruption of acute onset.

conclusionsThis case-crossover study showed evidence of an association between short-term ambient air pollution exposures and increased abruption risk of acute onset.

Indexed as

Abruptio PlacentaeAdultAir PollutionDelivery, ObstetricFemaleHumansLogistic ModelsNew York CityNitrogen DioxideParticulate MatterPregnancyRisk FactorsTime FactorsNitrogen DioxideParticulate Matter

Identifiers

PMID29863531
PMCPMC6066409

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.