ArticleAnnals of gastroenterological surgery2018
Detection of gas components as a novel diagnostic method for colorectal cancer.
Article in Annals of gastroenterological surgery, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 4 syntheses or guidelines pooled it, 34 citations in OpenAlex.
- Diagnostic performance of volatile organic compounds analysis and electronic noses for detecting colorectal cancer: a systematic review and meta-analysis.Frontiers in oncology · 2024Pooled it
- Volatile organic compounds as a potential screening tool for neoplasm of the digestive system: a meta-analysis.Scientific reports · 2021Pooled it
- Volatile organic compounds analysis as a potential novel screening tool for colorectal cancer: A systematic review and meta-analysis.Medicine · 2020Pooled it
- Fecal volatile organic compounds for early detection of colorectal cancer: where are we now?Journal of cancer research and clinical oncology · 2019Pooled it
- Use of Human Serum Albumin CysAntioxidants (Basel, Switzerland) · 2026Review
- Prognostic Significance of the Comprehensive Biomarker Analysis in Colorectal Cancer.Life (Basel, Switzerland) · 2025Review
- Sample Collection and Processing in Volatile Organic Compound Analysis for Gastrointestinal Cancers.Diagnostics (Basel, Switzerland) · 2024Review
- Bandgap engineering of germanene for gas sensing applications.RSC advances · 2023Article
- Methanethiol: A Scent Mark of Dysregulated Sulfur Metabolism in Cancer.Antioxidants (Basel, Switzerland) · 2023Review
- Systematic Review: Contribution of the Gut Microbiome to the Volatile Metabolic Fingerprint of Colorectal Neoplasia.Metabolites · 2022Review
- Biomarkers to Detect Early-Stage Colorectal Cancer.Biomedicines · 2022Review
- Novel Diagnostic Biomarkers in Colorectal Cancer.International journal of molecular sciences · 2022Review
- Sulphur metabolism in colon cancer tissues: a case report and literature review.The Journal of international medical research · 2021Review
- Review
- Towards Novel Non-Invasive Colorectal Cancer Screening Methods: A Comprehensive Review.Cancers · 2021Review
- Induced volatolomics of pathologies.Nature reviews. Chemistry · 2021Review
- A Review of GC-Based Analysis of Non-Invasive Biomarkers of Colorectal Cancer and Related Pathways.Journal of clinical medicine · 2020Review
- Biomarkers for detecting colorectal cancer non-invasively: DNA, RNA or proteins?World journal of gastrointestinal oncology · 2020Review
- Volatile organic compounds in breath can serve as a non-invasive diagnostic biomarker for the detection of advanced adenomas and colorectal cancer.Alimentary pharmacology & therapeutics · 2020Article
- Cys34 Adductomics Links Colorectal Cancer with the Gut Microbiota and Redox Biology.Cancer research · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe fecal occult blood test (FOBT) is widely accepted as the most economic and non-invasive screening method for colorectal cancer (CRC). However, the FOBT is inconvenient because it requires a fecal sample and shows limited accuracy. Alternatively, we hypothesized that fecal gas compounds from bowel movements may be a non-invasive biomarker for CRC.
methodsGas compounds were collected from the bowel movements of 30 patients with CRC and from 26 healthy controls. The patient group comprised 17 males and 13 females, and the average age was 68 years. Additionally, 22 patients had colon cancer, and eight patients had rectal cancer. Gas compounds were analyzed using gas chromatography and compared with those from healthy controls.
resultsIn the gas analysis, methyl mercaptan was significantly higher in the CRC group than in the control group. Hydrogen was significantly lower in the CRC group than in the control group and was correlated with tumor depth and advanced disease stage. Sensitivity, specificity, and accuracy of detection by a discriminant formula were 90%, 57.7%, and 75%, respectively.
conclusionGas compounds from defecation constitute a promising, novel non-invasive approach for CRC screening. (UMIN000028256).
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.