SynthesisJournal of epidemiology2018
A Dose-Response Meta-analysis of Coffee Consumption and Colorectal Cancer Risk in the Japanese Population: Application of a Cubic-Spline Model.
Synthesis in Journal of epidemiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 6 of them syntheses that pooled it.
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Who cites it
10 citing papers in PubMed, 6 syntheses or guidelines pooled it.
- Dietary factors and colorectal cancer risk in Asian populations: a systematic review and meta-analysis of cohort studies.Cancer causes & control : CCC · 2025Pooled it
- Does drinking coffee reduce the risk of colorectal cancer? A qualitative umbrella review of systematic reviews.Techniques in coloproctology · 2023Pooled it
- Coffee Consumption and Colon Cancer Risk: A Meta- Epidemiological Study of Asian Cohort Studies.Asian Pacific journal of cancer prevention : APJCP · 2020Pooled it
- Dose-response meta-analysis of coffee consumption and risk of colorectal adenoma.European journal of clinical nutrition · 2020Pooled it
- GWAS of habitual coffee consumption reveals a sex difference in the genetic effect of the 12q24 locus in the Japanese population.BMC genetics · 2019Pooled it
- Association between tea and coffee consumption and brain cancer risk: an updated meta-analysis.World journal of surgical oncology · 2019Pooled it
- Coffee consumption, cancer, and healthy aging: epidemiological evidence and underlying mechanisms.GeroScience · 2025Review
- Nine dietary habits and risk of colorectal cancer: a Mendelian randomization study.BMC medical genomics · 2024Article
- Coffee consumption by type and risk of digestive cancer: a large prospective cohort study.British journal of cancer · 2019Article
- The Impact of Coffee and Its Selected Bioactive Compounds on the Development and Progression of Colorectal Cancer In Vivo and In Vitro.Molecules (Basel, Switzerland) · 2018Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundA recent meta-analysis compared the relative risks of colorectal cancer between the highest and lowest levels of coffee consumption in the Japanese population. However, this analysis did not define the risks with respect to specific exposure values when considering levels of coffee consumption per day in the study population.
methodsWe conducted a two-stage random-effects dose-response meta-analysis of the association between coffee consumption and colorectal cancer among the Japanese. This was performed by modeling coffee consumption using restricted cubic splines to be able to examine a potential nonlinear relation.
resultsWe identified a total of 26 studies from seven articles, which were distributed separately according to sex and colon/rectum cancers. Data from 14 cohort studies showed that the pooled relative risks for colorectal cancers were less than 1.0 in cases with coffee consumption of 1-3 cups/day and 1.0 in cases with consumption of 4 cups/day or more, although these results were not statistically significant. Data from 12 case-control studies showed that the pooled odds ratios for cancer risk were significantly less than 1.0 in cases with coffee consumption of 1-6 cups/day.
conclusionsFindings from this meta-analysis indicate that moderate coffee consumption may not be associated or may be weakly inversely associated with the risk of colorectal cancer in the Japanese population.
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