ArticleNeural regeneration research2018
Validation of a novel animal model for sciatic nerve repair with an adipose-derived stem cell loaded fibrin conduit.
Article in Neural regeneration research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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Who cites it
20 citing papers in PubMed, 37 citations in OpenAlex.
- Host Response Impairs Tissue Integration of a Fibrin Hydrogel Scaffold Containing Poly(ε-caprolactone) Nanofibers for Peripheral Nerve Repair.Biomimetics (Basel, Switzerland) · 2026Article
- The fate of the neuromuscular junction in peripheral nerve injury - current understanding and future research aims: A scoping review.JPRAS open · 2026Review
- 3D printed nerve guidance conduit for biologics-free nerve regeneration and vascular integration.Bioengineering & translational medicine · 2025Article
- Mesenchymal stem cell-based therapy for peripheral nerve injuries: A promise or reality?World journal of stem cells · 2025Review
- Functional assessment of local versus systemic adipose-derived stromal cell therapy in rodent peripheral nerve regeneration.Frontiers in neurology · 2025Article
- Regenerative Medicine: A New Horizon in Peripheral Nerve Injury and Repair.Orthopedic reviews · 2025Article
- Longitudinally aligned inner-patterned silk fibroin conduits for peripheral nerve regeneration.In vitro models · 2023Article
- Potential of dental pulp stem cells and their products in promoting peripheral nerve regeneration and their future applications.World journal of stem cells · 2023Review
- Regenerative Strategies in Treatment of Peripheral Nerve Injuries in Different Animal Models.Tissue engineering and regenerative medicine · 2023Review
- Hypoxic pre-conditioned adipose-derived stem/progenitor cells embedded in fibrin conduits promote peripheral nerve regeneration in a sciatic nerve graft model.Neural regeneration research · 2023Article
- Micropattern-based nerve guidance conduit with hundreds of microchannels and stem cell recruitment for nerve regeneration.NPJ Regenerative medicine · 2022Article
- Role of adipose tissue grafting and adipose-derived stem cells in peripheral nerve surgery.Neural regeneration research · 2022Review
- Electrical stimulation of human neural stem cells via conductive polymer nerve guides enhances peripheral nerve recovery.Biomaterials · 2021Article
- Bioactive Nanofiber-Based Conduits in a Peripheral Nerve Gap Management-An Animal Model Study.International journal of molecular sciences · 2021Article
- Advances and clinical challenges for translating nerve conduit technology from bench to bed side for peripheral nerve repair.Cell and tissue research · 2021Review
- Effect of Systemic Adipose-derived Stem Cell Therapy on Functional Nerve Regeneration in a Rodent Model.Plastic and reconstructive surgery. Global open · 2020Article
- Ex-Vivo Stimulation of Adipose Stem Cells by Growth Factors and Fibrin-Hydrogel Assisted Delivery Strategies for Treating Nerve Gap-Injuries.Bioengineering (Basel, Switzerland) · 2020Article
- Restoration of Neurological Function Following Peripheral Nerve Trauma.International journal of molecular sciences · 2020Review
- Neural crest derived stem cells from dental pulp and tooth-associated stem cells for peripheral nerve regeneration.Neural regeneration research · 2020Review
- Neuromuscular Junction Changes in a Mouse Model of Charcot-Marie-Tooth Disease Type 4C.International journal of molecular sciences · 2018Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Despite the regenerative capabilities of peripheral nerves, severe injuries or neuronal trauma of critical size impose immense hurdles for proper restoration of neuro-muscular circuitry. Autologous nerve grafts improve re-establishment of connectivity, but also comprise substantial donor site morbidity. We developed a rat model which allows the testing of different cell applications, i.e., mesenchymal stem cells, to improve nerve regeneration in vivo. To mimic inaccurate alignment of autologous nerve grafts with the injured nerve, a 20 mm portion of the sciatic nerve was excised, and sutured back in place in reversed direction. To validate the feasibility of our novel model, a fibrin gel conduit containing autologous undifferentiated adipose-derived stem cells was applied around the coaptation sites and compared to autologous nerve grafts. After evaluating sciatic nerve function for 16 weeks postoperatively, animals were sacrificed, and gastrocnemius muscle weight was determined along with morphological parameters (g-ratio, axon density & diameter) of regenerating axons. Interestingly, the addition of undifferentiated adipose-derived stem cells resulted in a significantly improved re-myelination, axon ingrowth and functional outcome, when compared to animals without a cell seeded conduit. The presented model thus displays several intriguing features: it imitates a certain mismatch in size, distribution and orientation of axons within the nerve coaptation site. The fibrin conduit itself allows for an easy application of cells and, as a true critical-size defect model, any observed improvement relates directly to the performed intervention. Since fibrin and adipose-derived stem cells have been approved for human applications, the technique can theoretically be performed on humans. Thus, we suggest that the model is a powerful tool to investigate cell mediated assistance of peripheral nerve regeneration.
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Registered trials
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