ArticleThe international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease2018
TB preventive therapy for people living with HIV: key considerations for scale-up in resource-limited settings.
Article in The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
55 citing papers in PubMed, 84 citations in OpenAlex.
- Health care providers acceptance of default prescribing of TB preventive treatment for people living with HIV in Malawi: a qualitative study.BMC health services research · 2024Trial
- Understanding Barriers to Uptake of TB Preventive Treatment Among People Living with HIV in Zimbabwe: A Qualitative Assessment of Healthcare Workers' Perspectives.Tropical medicine and infectious disease · 2026Article
- Embracing Tuberculosis Preventive Treatment: A Crucial Step towards TB Control in Pakistan.Pakistan journal of medical sciences · 2026Article
- Ending Tuberculosis through prevention: Zimbabwe's PEPFAR Tuberculosis preventive treatment scale-up journey (2016-2024).International journal of STD & AIDS · 2026Article
- Mapping facility-based tuberculosis preventive treatment provision in Ethiopia: a geospatial analysis.BMC health services research · 2026Article
- Tuberculosis Prevention in Pregnant Women Living with HIV: A Review of the Current Management Strategies and Guidance.Infection and drug resistance · 2026Review
- Barriers and facilitators to implementing an integrated electronic health records system to improve tuberculosis preventive treatment among people living with HIV: a content analysis study from Georgia.Frontiers in digital health · 2026Article
- Analysis of Tuberculosis Preventive Treatment Cascade Among People With Human Immunodeficiency Virus in Georgia: A Mixed-Methods Study.Open forum infectious diseases · 2026Article
- Optimization of Case Finding and Preventive Treatment Among Household Contacts of People with Tuberculosis in Zimbabwe.Tropical medicine and infectious disease · 2025Article
- Evaluation of Tuberculosis Preventive Treatment Uptake Among People Living with HIV in PEPFAR-Supported Facilities in Zimbabwe.Tropical medicine and infectious disease · 2025Article
- Between Process Gaps, Knowledge, and Patient Trust: Healthcare Workers' Insights on Implementing Tuberculosis Preventive Therapy for People with HIV in the Philippines and Indonesia.Implementation science communications · 2025Article
- 'And the stick to fight TB is TPT': nurse-identified barriers and facilitators of tuberculosis preventive therapy implementation in rural South Africa.BMJ open respiratory research · 2025Article
- Application of causal forest double machine learning (DML) approach to assess tuberculosis preventive therapy's impact on ART adherence.Scientific reports · 2025Article
- Rapid Antiretroviral Therapy Initiation Reduces Mortality Among People Living With HIV in Indonesia: A Retrospective Observational Study.Journal of preventive medicine and public health = Yebang Uihakhoe chi · 2025Observational
- Advancement in diagnostic approaches for latent tuberculosis: distinguishing recent from remote infections.One health outlook · 2025Review
- Tuberculosis Preventive Treatment in High TB-Burden Settings: A State-of-the-Art Review.Drugs · 2025Review
- Innovations in TB Screening and Preventive Therapy Services for PLHIV in Yogyakarta City, Indonesia.Tropical medicine and infectious disease · 2025Article
- Time-dependent predictors of loss to follow-up in HIV care in low-resource settings: A competing risks approach.PloS one · 2025Article
- "Now that I took TPT, it's affecting my ART adherence, viral load, even my wellbeing in the community". Exploring acceptability and experience of Tuberculosis Preventive Treatment among adolescents living with HIV in Zimbabwe.PLOS global public health · 2025Article
- Intersecting Epidemics: The Predictors of Continued Utilization of HIV Care and Treatment Services During the COVID-19 Outbreak Among People Living with HIV in ZIMBABWE.AIDS and behavior · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
Tuberculosis (TB) is the leading cause of death for persons living with the human immunodeficiency virus (PLHIV). TB preventive therapy (TPT) works synergistically with, and independently of, antiretroviral therapy to reduce TB morbidity, mortality and incidence among PLHIV. However, although TPT is a crucial and cost-effective component of HIV care for adults and children and has been recommended as an international standard of care for over a decade, it remains highly underutilized. If we are to end the global TB epidemic, we must address the significant reservoir of tuberculous infection, especially in those, such as PLHIV, who are most likely to progress to TB disease. To do so, we must confront the pervasive perception that barriers to TPT scale-up are insurmountable in resource-limited settings. Here we review available evidence to address several commonly stated obstacles to TPT scale-up, including the need for the tuberculin skin test, limited diagnostic capacity to reliably exclude TB disease, concerns about creating drug resistance, suboptimal patient adherence to therapy, inability to monitor for and prevent adverse events, a 'one size fits all' option for TPT regimen and duration, and uncertainty about TPT use in children, adolescents, and pregnant women. We also discuss TPT delivery in the era of differentiated care for PLHIV, how best to tackle advanced planning for drug procurement and supply chain management, and how to create an enabling environment for TPT scale-up success.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.