Evidence map›Paper›PMID 29862889›Full record

ArticleReproductive sciences (Thousand Oaks, Calif.)2019

Effect of Mode of Conception on Maternal Serum Relaxin, Creatinine, and Sodium Concentrations in an Infertile Population.

Frauke von Versen-Höynck, Nairi K Strauch, Jing Liu, Yueh-Yun Chi, Maureen Keller-Woods, Kirk P Conrad, Valerie L Baker

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Reproductive sciences (Thousand Oaks, Calif.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 5 pooled it
9.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 5 syntheses or guidelines pooled it, 86 citations in OpenAlex.

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  5. Fresh versus frozen embryo transfers in assisted reproduction.The Cochrane database of systematic reviews · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Frauke von Versen-Höynck1 Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Stanford University Medical Center, Sunnyvale, CA, USA.
Nairi K Strauch1 Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Stanford University Medical Center, Sunnyvale, CA, USA.
Jing Liu3 Department of Biostatistics, University of Florida, Gainesville, FL, USA.
Yueh-Yun Chi3 Department of Biostatistics, University of Florida, Gainesville, FL, USA.
Maureen Keller-Woods4 Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, FL, USA.
Kirk P Conrad5 Department of Physiology and Functional Genomics, D. H. Barron Reproductive and Perinatal Biology Research Program, College of Medicine, University of Florida, Gainesville, FL, USA.
Valerie L Baker1 Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Stanford University Medical Center, Sunnyvale, CA, USA.
University of Florida · USStanford Medicine · US

Funding

Mechanisms & Consequences of Vascular Adaptations in Pregnancies Conceived by ARTP01HD065647 · NICHD · UNIVERSITY OF FLORIDA · PI CONRAD, KIRK P · 2011 to 2016
$6.1M
NICHD NIH HHS P01 HD065647NIH HHS P01 HD 065647-01A1
6 · The paper itself

Abstract

objectiveTo investigate how the mode of conception affects maternal relaxin, creatinine, and electrolyte concentrations.

backgroundPregnancies achieved by fertility treatment often begin in a nonphysiologic endocrine milieu with no corpus luteum (CL) or with many corpora lutea. The CL produces not only estradiol and progesterone but is also the sole source of relaxin in early pregnancy, a hormone that may contribute to maternal systemic and renal vasodilation. There is limited data about maternal physiology in early pregnancy during fertility treatment, and studies have rarely considered the potential effect of the absence of the CL. To begin to address this gap in knowledge, we sought to investigate how the mode of conception affects maternal relaxin, creatinine, and electrolyte concentrations.

methodsOne hundred eighty-four women who received care at an academic infertility practice provided serum samples. Levels of relaxin 2, creatinine, and electrolytes were compared between 4 groups defined on the basis of mode of conception which corresponded to categories of CL number: (1) absence of the CL, (2) single CL, (3) multiple CL from ovarian stimulation not including in vitro fertilization (IVF), and (4) multiple CL from IVF with fresh embryo transfer.

resultsRelaxin-2 levels were undetectable in patients lacking a CL. Creatinine, sodium, and total CO

conclusionEarly creatinine and sodium concentrations are increased in the absence of relaxin. Given the increasing utilization of frozen embryo transfer, further studies comparing programmed with natural cycles are warranted.

Indexed as

Reproductive Techniques, AssistedAdultCorpus LuteumCreatineFemaleHumansInfertility, FemaleMiddle AgedPregnancyRelaxinSodiumCreatineRelaxinSodiumassisted reproductioncorpus luteumfemale infertilitypregnancyrelaxin

Identifiers

PMID29862889
PMCPMC6728556
OpenAlexW2806828178

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.