Evidence map›Paper›PMID 29862879›Full record

ArticleJournal of intensive care medicine2020

Mediating Effects of Frailty Indicators on the Risk of Sepsis After Cancer.

Justin Xavier Moore, Tomi Akinyemiju, Alfred Bartolucci, Henry E Wang, John Waterbor, Russell Griffin

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of intensive care medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Frailty and aging in cancer survivors.Translational research : the journal of laboratory and clinical medicine · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Justin Xavier MooreDepartment of Epidemiology, University of Alabama at Birmingham, Birmingham, AL, USA.
Tomi AkinyemijuDepartment of Epidemiology, University of Alabama at Birmingham, Birmingham, AL, USA.
Alfred BartolucciDepartment of Biostatistics, University of Alabama at Birmingham, Birmingham, AL, USA.
Henry E WangDepartment of Emergency Medicine, University of Texas Health Science Center at Houston, Houston, TX, USA.
John WaterborDepartment of Epidemiology, University of Alabama at Birmingham, Birmingham, AL, USA.
Russell GriffinDepartment of Epidemiology, University of Alabama at Birmingham, Birmingham, AL, USA.
University of Alabama at Birmingham · USThe University of Texas Health Science Center at Houston · USWashington University in St. Louis · US

Funding

VCID and Stroke in a Bi-racial National CohortU01NS041588 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI CUSHMAN, MARY, HOWARD, GEORGE · 2002 to 2022
$96.0M
National Dissemination of I-Corps@NCATS: Accelerating Translation through CommercializationUL1TR003096 · NCATS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI GUTIERREZ, ORLANDO M, KIMBERLY, ROBERT P. · 2019 to 2023
$43.6M
UAB Center for Clinical and Translational Science (CCTS)UL1TR001417 · NCATS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI KIMBERLY, ROBERT P. · 2015 to 2018
$31.4M
UAB CENTER FOR CLINICAL AND TRANSLATIONAL SCIENCE (CCTS) UL1: BPCAUL1RR025777 · NCRR · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI GUAY-WOODFORD, LISA MARIE · 2008 to 2011
$22.3M
Cancer Prevention & Control Training ProgramR25CA047888 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI DEMARK-WAHNEFRIED, WENDY, MENESES, KAREN M · 1988 to 2016
$11.2M
Postdoctoral Training in Cancer Prevention and ControlT32CA190194 · NCI · WASHINGTON UNIVERSITY · PI GRAHAM A. COLDITZ, AIMEE S JAMES · 2014 to 2026
$4.7M
Risk Factors for Sepsis in the CommunityR01NR012726 · NINR · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI WANG, HENRY E. · 2011 to 2015
$2.6M
NCATS NIH HHS UL1 TR001417NCATS NIH HHS UL1 TR003096NCI NIH HHS R25 CA047888NCI NIH HHS T32 CA190194NCRR NIH HHS UL1 RR025777NINDS NIH HHS U01 NS041588NINR NIH HHS R01 NR012726
6 · The paper itself

Abstract

backgroundCancer survivors are at increased risk of sepsis, possibly attributed to weakened physiologic conditions. The aims of this study were to examine the mediation effect of indicators of frailty on the association between cancer survivorship and sepsis incidence and whether these differences varied by race.

methodsWe performed a prospective analysis using data from the REasons for Geographic and Racial Differences in Stroke cohort from years 2003 to 2012. We categorized frailty as the presence of ≥2 frailty components (weakness, exhaustion, and low physical activity). We categorized participants as "cancer survivors" or "no cancer history" derived from self-reported responses of being diagnosed with any cancer. We examined the mediation effect of frailty on the association between cancer survivorship and sepsis incidence using Cox regression. We repeated analysis stratified by race.

resultsAmong 28 062 eligible participants, 2773 (9.88%) were cancer survivors and 25 289 (90.03%) were no cancer history participants. Among a total 1315 sepsis cases, cancer survivors were more likely to develop sepsis (12.66% vs 3.81%,

conclusionCancer survivors had more than a 2-fold increased risk of sepsis, and indicators of frailty contributed to less than 1% of this disparity.

Indexed as

AgedCancer SurvivorsFemaleFrailtyHumansIncidenceMaleMiddle AgedNeoplasmsProspective StudiesRacial GroupsRisk FactorsSepsisand Racial DisparitiesCancerFrailtyMediationSepsis

Identifiers

PMID29862879
PMCPMC6026551
OpenAlexW2806147122

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.