Evidence map›Paper›PMID 29862863›Full record

ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2019

A critical role for the ATP-sensitive potassium channel subunit K

Patrick S Hosford, Isabel N Christie, Arun Niranjan, Qadeer Aziz, Naomi Anderson, Richard Ang, Mark F Lythgoe, Jack A Wells, Andrew Tinker, Alexander V Gourine

Open access · hybridAbstract read
In one paragraph

Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 2 pooled it
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 2 syntheses or guidelines pooled it, 40 citations in OpenAlex.

  1. Pooled it
  2. CONature communications · 2022
    Pooled it
  3. Cerebrovascular effects of glibenclamide investigated using high-resolution magnetic resonance imaging in healthy volunteers.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021
    Trial
  4. Article
  5. Review
  6. Review
  7. Article
  8. Eppur si muove: the dynamic brain pericyte.Fluids and barriers of the CNS · 2025
    Review
  9. Pericyte Electrical Signalling and Brain Haemodynamics.Basic & clinical pharmacology & toxicology · 2025
    Review
  10. KProceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Review
  16. Do KFrontiers in immunology · 2024
    Review
  17. Review
  18. Article
  19. Article
  20. Abnormal brain oxygen homeostasis in an animal model of liver disease.JHEP reports : innovation in hepatology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Patrick S HosfordWilliam Harvey Research Institute, Barts and the London School of Medicine and Dentistry, London, UK.
Isabel N ChristieCentre for Cardiovascular and Metabolic Neuroscience, Neuroscience, Physiology & Pharmacology, University College London, London, UK.
Arun NiranjanUCL Centre for Advanced Biomedical Imaging, Division of Medicine, University College London, London, UK.
Qadeer AzizWilliam Harvey Research Institute, Barts and the London School of Medicine and Dentistry, London, UK.
Naomi AndersonWilliam Harvey Research Institute, Barts and the London School of Medicine and Dentistry, London, UK.
Richard AngCentre for Cardiovascular and Metabolic Neuroscience, Neuroscience, Physiology & Pharmacology, University College London, London, UK.
Mark F LythgoeUCL Centre for Advanced Biomedical Imaging, Division of Medicine, University College London, London, UK.
Jack A WellsUCL Centre for Advanced Biomedical Imaging, Division of Medicine, University College London, London, UK.
Andrew TinkerWilliam Harvey Research Institute, Barts and the London School of Medicine and Dentistry, London, UK.
Alexander V GourineCentre for Cardiovascular and Metabolic Neuroscience, Neuroscience, Physiology & Pharmacology, University College London, London, UK.
University College London · GBWilliam Harvey Research Institute · GB

Funding

AUTOREGULATION OF HINDLIMB BLOOD FLOWK04HL001515 · NHLBI · UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS · PI BRITTON, STEVEN LOYAL · 1985 to 1989
–
British Heart Foundation RG/15/15/31742Department of HealthMedical Research Council G0901948Medical Research Council MR/K026739/1Wellcome Trust 200893/Z/16/ZWellcome Trust 204624/Z/16/Z
6 · The paper itself

Abstract

K

Indexed as

Cerebrovascular CirculationAdenosine TriphosphateAnimalsBrainKATP ChannelsMaleMiceOxygenAdenosine TriphosphateKATP ChannelsOxygenuK-ATP-1 potassium channelCerebral blood flowcerebrovascular reactivityfunctional magnetic resonance imaginghypoxianeurovascular coupling

Identifiers

PMID29862863
PMCPMC6775590
OpenAlexW2806655385

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.