Evidence map›Paper›PMID 29862657›Full record

ArticleAngewandte Chemie (International ed. in English)2018

Late-Stage Isotopic Carbon Labeling of Pharmaceutically Relevant Cyclic Ureas Directly from CO

Antonio Del Vecchio, Fabien Caillé, Arnaud Chevalier, Olivier Loreau, Kaisa Horkka, Christer Halldin, Magnus Schou, Nathalie Camus, Pascal Kessler, Bertrand Kuhnast and 2 more

Abstract read
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. It's a Gas: Bioconjugation With Vapor-Phase Reagents.Chemistry (Weinheim an der Bergstrasse, Germany) · 2026
    Review
  2. Review
  3. Copper-Catalyzed Carbonylative Cyclization of COAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  4. Review
  5. Article
  6. Electrocatalytic Reactions for Converting COInternational journal of molecular sciences · 2023
    Review
  7. Review
  8. Review
  9. Article
  10. Review
  11. Article
  12. Copper-Mediated Radiocyanation of Unprotected Amino Acids and Peptides.Journal of the American Chemical Society · 2022
    Article
  13. Article
  14. Transition-Metal-Free Carbon Isotope Exchange of Phenyl Acetic Acids.Angewandte Chemie (International ed. in English) · 2020
    Article
  15. [Angewandte Chemie (International ed. in English) · 2020
    Article
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Antonio Del VecchioService de Chimie Bio-organique et de Marquage, CEA-DRF-JOLIOT-SCBM, Université Paris-Saclay, 91191, Gif sur Yvette, France.ORCID 0000-0001-9759-4420
Fabien CailléUMR 1023 IMIV, Service Hospitalier Frédéric Joliot, CEA, Inserm, Université Paris Sud, CNRS, Université Paris-Saclay, Orsay, France.ORCID 0000-0003-0088-7337
Arnaud ChevalierService de Chimie Bio-organique et de Marquage, CEA-DRF-JOLIOT-SCBM, Université Paris-Saclay, 91191, Gif sur Yvette, France.
Olivier LoreauService de Chimie Bio-organique et de Marquage, CEA-DRF-JOLIOT-SCBM, Université Paris-Saclay, 91191, Gif sur Yvette, France.
Kaisa HorkkaPsychiatry Section, Department of Clinical Neuroscience, Karolinska Institutet, 171 76, Stockholm, Sweden.
Christer HalldinPsychiatry Section, Department of Clinical Neuroscience, Karolinska Institutet, 171 76, Stockholm, Sweden.
Magnus SchouPsychiatry Section, Department of Clinical Neuroscience, Karolinska Institutet, 171 76, Stockholm, Sweden.
Nathalie CamusService de Chimie Bio-organique et de Marquage, CEA-DRF-JOLIOT-SCBM, Université Paris-Saclay, 91191, Gif sur Yvette, France.
Pascal KesslerService d'Ingénierie Moléculaire des Protéines, CEA-DRF-JOLIOT-SIMOPRO, Université Paris-Saclay, 91191, Gif sur Yvette, France.
Bertrand KuhnastUMR 1023 IMIV, Service Hospitalier Frédéric Joliot, CEA, Inserm, Université Paris Sud, CNRS, Université Paris-Saclay, Orsay, France.
Frédéric TaranService de Chimie Bio-organique et de Marquage, CEA-DRF-JOLIOT-SCBM, Université Paris-Saclay, 91191, Gif sur Yvette, France.
Davide AudisioService de Chimie Bio-organique et de Marquage, CEA-DRF-JOLIOT-SCBM, Université Paris-Saclay, 91191, Gif sur Yvette, France.ORCID 0000-0002-6234-3610

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A robust, click-chemistry-inspired procedure for radiolabeling of cyclic ureas was developed. This protocol, suitable for all carbon isotopes (

Indexed as

Isotope LabelingCarbon DioxideCarbon IsotopesClick ChemistryMolecular StructureRadiopharmaceuticalsUreaCarbon DioxideCarbon IsotopesRadiopharmaceuticalsUreacarbon-11carbon-14carbon dioxideheterocyclesisotopic labeling

Identifiers

PMID29862657
PMCPMC6099343

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.