Evidence map›Paper›PMID 29862485›Full record

ArticleDigestive diseases and sciences2018

Smoking and Inflammatory Bowel Disease: A Comparison of China, India, and the USA.

Peiqi Wang, Jun Hu, Shadi Ghadermarzi, Ali Raza, Douglas O'Connell, Amy Xiao, Faraz Ayyaz, Min Zhi, Yuanqi Zhang, Nimisha K Parekh and 8 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Digestive diseases and sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 3 pooled it
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 3 syntheses or guidelines pooled it, 40 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Diet and inflammatory bowel disease: The Asian Working Group guidelines.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2019
    Guideline
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  5. Review
  6. Article
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  11. Review
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  14. Ulcerative colitis.Nature reviews. Disease primers · 2020
    Review
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  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 8 institutions in 4 countries.

Peiqi WangDepartment of Surgery, Johns Hopkins University, Baltimore, MD, USA.
Jun HuDepartment of Gastroenterology, The Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Shadi GhadermarziDepartment of Internal Medicine, East Carolina University, Greenville, NC, USA.
Ali RazaDepartment of Cardiology, Boston Children's Hospital, Harvard Medical School, Boston, MD, USA.
Douglas O'ConnellSchool of Medicine, Division of Gastroenterology, University of California, Irvine, USA.
Amy XiaoDepartment of Biomedical Engineering, Whiting School of Engineering, Johns Hopkins University, Baltimore, MD, USA.
Faraz AyyazServices Institute of Medical Sciences, Lahore, Pakistan.
Min ZhiDepartment of Gastroenterology, The Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Yuanqi ZhangDepartment of Gastroenterology, The Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Nimisha K ParekhSchool of Medicine, Division of Gastroenterology, University of California, Irvine, USA.
Mark LazarevDepartment of Medicine, Division of Gastroenterology and Hepatology, Meyerhoff Inflammatory Bowel Disease Center, Johns Hopkins University, Baltimore, MD, USA.
Alyssa ParianDepartment of Medicine, Division of Gastroenterology and Hepatology, Meyerhoff Inflammatory Bowel Disease Center, Johns Hopkins University, Baltimore, MD, USA.
Steven R BrantDepartment of Medicine, Division of Gastroenterology and Hepatology, Rutgers Health, Robert Wood Johnson Medical School, New Brunswick, NJ, USA.
Marshall BedineDepartment of Medicine, Division of Gastroenterology and Hepatology, Meyerhoff Inflammatory Bowel Disease Center, Johns Hopkins University, Baltimore, MD, USA.
Brindusa TrutaDepartment of Medicine, Division of Gastroenterology and Hepatology, Meyerhoff Inflammatory Bowel Disease Center, Johns Hopkins University, Baltimore, MD, USA.
Pinjin HuDepartment of Gastroenterology, The Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Rupa BanerjeeAsian Institute of Gastroenterology, Hyderabad, India.
Susan M HutflessDivision of Gastroenterology and Hepatology, Gastrointestinal Epidemiology Research Center, Johns Hopkins University, 600 N Wolfe St, Blalock 449, Baltimore, MD, 21287, USA. shutfle1@jhmi.edu.ORCID http://orcid.org/0000-0002-6311-2611
Johns Hopkins University · USSun Yat-sen University · CNUniversity of California, Irvine · USAsian Institute of Gastroenterology · INBoston Children's Hospital · USEast Carolina University · USRutgers, The State University of New Jersey · USServices Institute of Medical Sciences · PK

Funding

Institute for Clinical and Translational ResearchUL1TR001079 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2013 to 2017
$60.1M
Translational Research Enhancement CoreP30DK089502 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI ZACHOS, NICHOLAS CONSTANTINE · 2011 to 2020
$12.0M
Johns Hopkins University Ludwig-Bayless Science AwardJohns Hopkins University UL1 TR 001079NCATS NIH HHS UL1 TR001079NIDDK NIH HHS P30 DK089502Sun Yat-sen University (CN) 2014008
6 · The paper itself

Abstract

backgroundCigarette smoking is thought to increase the risk of Crohn's disease (CD) and exacerbate the disease course, with opposite roles in ulcerative colitis (UC). However, these findings are from Western populations, and the association between smoking and inflammatory bowel disease (IBD) has not been well studied in Asia.

aimsWe aimed to compare the prevalence of smoking at diagnosis between IBD cases and controls recruited in China, India, and the USA, and to investigate the impact of smoking on disease outcomes.

methodsWe recruited IBD cases and controls between 2014 and 2018. All participants completed a questionnaire about demographic characteristics, environmental risk factors and IBD history.

resultsWe recruited 337 participants from China, 194 from India, and 645 from the USA. In China, CD cases were less likely than controls to be current smokers (adjusted odds ratio [95% CI] 0.4 [0.2-0.9]). There was no association between current or former smoking and CD in the USA. In China and the USA, UC cases were more likely to be former smokers than controls (China 14.6 [3.3-64.8]; USA 1.8 [1.0-3.3]). In India, both CD and UC had similar current smoking status to controls at diagnosis. Current smoking at diagnosis was significantly associated with greater use of immunosuppressants (4.4 [1.1-18.1]) in CD cases in China.

conclusionsWe found heterogeneity in the associations of smoking and IBD risk and outcomes between China, India, and the USA. Further study with more adequate sample size and more uniform definition of smoking status is warranted.

Indexed as

Cigarette SmokingInflammatory Bowel DiseasesAdultCase-Control StudiesChinaCross-Cultural ComparisonFemaleHumansImmunosuppressive AgentsIndiaMaleMiddle AgedPrevalenceProtective FactorsRisk FactorsStatistics as TopicImmunosuppressive AgentsAsiaCrohn’s diseaseEnvironmentSmokingUlcerative colitis

Identifiers

PMID29862485
PMCPMC6435261
OpenAlexW2806573297

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.