Evidence map›Paper›PMID 29862415›Full record

ArticleHistochemistry and cell biology2018

Resistance to neomycin ototoxicity in the extreme basal (hook) region of the mouse cochlea.

Shelly C Y Lin, Peter R Thorne, Gary D Housley, Srdjan M Vlajkovic

Abstract read
PubMed Publisher
In one paragraph

Article in Histochemistry and cell biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.4field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. NOX2 Contributes to High-Frequency Outer Hair Cell Vulnerability in the Cochlea.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  3. Article
  4. PGC-1Acta pharmaceutica Sinica. B · 2024
    Article
  5. Article
  6. The regenerative capacity of neonatal tissues.Development (Cambridge, England) · 2022
    Review
  7. Article
  8. Article
  9. In focus in HCB.Histochemistry and cell biology · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Shelly C Y LinDepartment of Physiology and The Eisdell Moore Centre, Faculty of Medical and Health Sciences, The University of Auckland, Private Bag 92019, Auckland, New Zealand. shelly.lin@auckland.ac.nz.
Peter R ThorneDepartment of Physiology and The Eisdell Moore Centre, Faculty of Medical and Health Sciences, The University of Auckland, Private Bag 92019, Auckland, New Zealand.
Gary D HousleyDepartment of Physiology and Translational Neuroscience Facility, School of Medical Sciences, UNSW, Sydney, NSW, 2052, Australia.
Srdjan M VlajkovicDepartment of Physiology and The Eisdell Moore Centre, Faculty of Medical and Health Sciences, The University of Auckland, Private Bag 92019, Auckland, New Zealand.
University of Auckland · NZUNSW Sydney · AU

Funding

Auckland Medical Research Foundation 1110013
6 · The paper itself

Abstract

Aminoglycoside ototoxicity results in permanent loss of the sensory hair cells in the mammalian cochlea. It usually begins at the basal turn causing high-frequency hearing loss. Here we describe previously unreported resistance of hair cells to neomycin ototoxicity in the extreme basal (hook) region of the developing cochlea of the C57BL/6 mouse. Organ of Corti explants from mice at postnatal day 3 were incubated (37 °C, 5% CO

Indexed as

AnimalsCochleaHair Cells, Auditory, OuterMiceMice, Inbred C57BLNeomycinOrgan Culture TechniquesTissue DistributionNeomycinAminoglycoside ototoxicityC57BL/6 mouseCochlear explantHook regionNeomycinSensory hair cells

Identifiers

PMID29862415
OpenAlexW2807304844

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.