Evidence map›Paper›PMID 29862413›Full record

ArticleNeuroradiology2018

Quantitative sodium imaging and gliomas: a feasibility study.

Lucidio P Nunes Neto, Guillaume Madelin, Terlika Pandit Sood, Chih-Chun Wu, Douglas Kondziolka, Dimitris Placantonakis, John G Golfinos, Andrew Chi, Rajan Jain

Open access · greenAbstract read
In one paragraph

Article in Neuroradiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 32 citations in OpenAlex.

  1. Triple-PulseMagnetic resonance in medicine · 2026
    Article
  2. The Role of MRI in Debunking the Fallacy of "Mild" Traumatic Brain Injury.Journal of magnetic resonance imaging : JMRI · 2026
    Review
  3. Article
  4. Sodium MRI in Pediatric Brain Tumors.AJNR. American journal of neuroradiology · 2025
    Review
  5. Review
  6. European radiology experimental · 2024
    Article
  7. Article
  8. Review
  9. Sodium MR Neuroimaging.AJNR. American journal of neuroradiology · 2021
    Review
  10. Frontiers of Sodium MRI Revisited: From Cartilage to Brain Imaging.Journal of magnetic resonance imaging : JMRI · 2021
    Review
  11. Article
  12. Journal of magnetic resonance imaging : JMRI · 2021
    Review
  13. Review
  14. Comparison of [Molecular imaging and biology · 2020
    Article
  15. Sodium homeostasis in the tumour microenvironment.Biochimica et biophysica acta. Reviews on cancer · 2019
    Review
  16. Beyond T2 and 3T: New MRI techniques for clinicians.Clinical and translational radiation oncology · 2019
    Review
  17. Review
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Lucidio P Nunes NetoDepartment of Radiology, New York University School of Medicine, 660 1st Avenue, New York, 10016, NY, USA.
Guillaume MadelinDepartment of Radiology, New York University School of Medicine, 660 1st Avenue, New York, 10016, NY, USA.
Terlika Pandit SoodDepartment of Radiology, New York University School of Medicine, 660 1st Avenue, New York, 10016, NY, USA.
Chih-Chun WuDepartment of Radiology, New York University School of Medicine, 660 1st Avenue, New York, 10016, NY, USA.
Douglas KondziolkaDepartment of Neurosurgery, New York University School of Medicine, 660 1st Avenue, New York, 10016, NY, USA.
Dimitris PlacantonakisDepartment of Neurosurgery, New York University School of Medicine, 660 1st Avenue, New York, 10016, NY, USA.
John G GolfinosDepartment of Neurosurgery, New York University School of Medicine, 660 1st Avenue, New York, 10016, NY, USA.
Andrew ChiDepartment of Medicine, New York University School of Medicine, 660 1st Avenue, New York, 10016, NY, USA.
Rajan JainDepartment of Radiology, New York University School of Medicine, 660 1st Avenue, New York, 10016, NY, USA. rajan.jain@nyumc.org.
New York University · US

Funding

TR&D 4: Revealing Microstructure: Biophysical modeling and validation for discovery and clinical careP41EB017183 · NIBIB · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Hersh Chandarana · 2014 to 2026
$19.3M
Quantitative Sodium MR Imaging and Proton MR Spectroscopy in Traumatic Brain InjuryR01NS097494 · NINDS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI KIROV, IVAN IVANOV, MADELIN, GUILLAUME · 2016 to 2020
$2.4M
Metabolic Sodium MRI to Assess Early Response of Breast Cancer to Neoadjuvant ChemotherapyR21CA213169 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI BROWN, RYAN, MADELIN, GUILLAUME · 2017 to 2018
$406k
Sodium MRI of the HipR03AR065763 · NIAMS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI MADELIN, GUILLAUME · 2014 to 2015
$170k
National Institutes of Health 1R01NS097494National Institutes of Health (US) 1P41EB017183National Institutes of Health (US) 1R03AR065763National Institutes of Health (US) 1R21CA213169NCI NIH HHS R21 CA213169NIAMS NIH HHS R03 AR065763NIBIB NIH HHS P41 EB017183NINDS NIH HHS R01 NS097494
6 · The paper itself

Abstract

purposeRecent advances in sodium brain MRI have allowed for increased signal-to-noise ratio, faster imaging, and the ability of differentiating intracellular from extracellular sodium concentration, opening a new window of opportunity for clinical application. In gliomas, there are significant alterations in sodium metabolism, including increase in the total sodium concentration and extracellular volume fraction. The purpose of this study is to assess the feasibility of using sodium MRI quantitative measurements to evaluate gliomas.

methodsEight patients with treatment-naïve gliomas were scanned at 3 T with a homemade

resultsThe normal-appearing putamen demonstrated significantly higher values for aTSC, aISC, C

conclusionQuantitative sodium measurements can be done in glioma patients and also has provided further evidence that total sodium and extracellular volume fraction are increased in gliomas.

Indexed as

AdultBrain NeoplasmsFeasibility StudiesFemaleGliomaHumansImage Interpretation, Computer-AssistedMagnetic Resonance ImagingMaleNeoplasm GradingSodiumSodiumGliomaSodium MRI

Identifiers

PMID29862413
PMCPMC6070137
OpenAlexW2806277158

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.