Evidence map›Paper›PMID 29862378›Full record

ArticleInternal medicine review (Washington, D.C. : Online)2016

Purinergic P2X Receptors and Heightened Exercise Pressor Reflex in Peripheral Artery Disease.

Jianhua Li, Jian Cui

Open access · diamondAbstract read
In one paragraph

Article in Internal medicine review (Washington, D.C. : Online), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 78% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Jianhua LiHeart & Vascular Institute, The Penn State University College of Medicine, Hershey, PA 17033.
Jian CuiHeart & Vascular Institute, The Penn State University College of Medicine, Hershey, PA 17033.
Penn State Milton S. Hershey Medical Center · US

Funding

The Muscle Reflex: Modes of Engagement and Circulatory ConsequencesP01HL096570 · NHLBI · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI LEUENBERGER, URS A · 2010 to 2014
$9.9M
Sympathetic Nervous System and Heart Failure-Role of Primary Afferent NeuronsR01HL090720 · NHLBI · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI LI, JIANHUA · 2009 to 2010
$776k
NHLBI NIH HHS P01 HL096570NHLBI NIH HHS R01 HL090720
6 · The paper itself

Abstract

Arterial blood pressure (BP) and vasoconstriction regulated by sympathetic nerve activity (SNA) are heightened during exercise in patients with peripheral artery disease (PAD). The exercise pressor reflex is considered as a neural mechanism responsible for the exaggerated autonomic responses to exercise in PAD. A series of studies have employed a rat model of PAD to examine signal pathways at receptor and cellular levels by which the exercise pressor reflex is amplified. This review will summarize results obtained from recent human and animal studies with respect to contribution of muscle afferents to augmented SNA and BP responses in PAD. The role played by adenosine triphosphate (ATP) and ATP sensitive purinergic P2X receptors will be emphasized.

Indexed as

blood pressurebradykininmuscle temperaturenerve growth factorP2Xperipheral artery diseasestatic exercisesympathetic nerve activity

Identifiers

PMID29862378
PMCPMC5984049
OpenAlexW2560479236

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.