ArticleNeurobiology of pain (Cambridge, Mass.)
Amplified parabrachial nucleus activity in a rat model of trigeminal neuropathic pain.
Article in Neurobiology of pain (Cambridge, Mass.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 50 citations in OpenAlex.
- Peripheral NabioRxiv : the preprint server for biology · 2026Article
- Article
- Parabrachial bombesin receptor subtype 3 neurons facilitate heat hypersensitivity in persistent pain.bioRxiv : the preprint server for biology · 2026Article
- A Tac1-Expressing Brainstem Pathway Underlies the Pathogenesis of Trigeminal Neuralgia.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- The dorsal column nuclei encode and transmit the network signatures of mechanical allodynia.Cell reports · 2025Article
- Sex Differences in Central Amygdala Glutamate Responses to Calcitonin Gene-Related Peptide.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Delineation of the trigeminal-lateral parabrachial-central amygdala tract in humans.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Sex differences in central amygdala glutamate responses to calcitonin gene-related peptide.bioRxiv : the preprint server for biology · 2024Article
- Dysfunction of Small-Conductance CaCells · 2024Article
- Transient cAMP production drives rapid and sustained spiking in brainstem parabrachial neurons to suppress feeding.Neuron · 2024Article
- The parabrachial to central amygdala pathway is critical to injury-induced pain sensitization in mice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Divergent changes in PBN excitability in a mouse model of neuropathic pain.bioRxiv : the preprint server for biology · 2023Article
- Direct and Indirect Nociceptive Input from the Trigeminal Dorsal Horn to Pain-Modulating Neurons in the Rostral Ventromedial Medulla.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Parabrachial Nucleus Activity in Nociception and Pain in Awake Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Parabrachial nucleus activity in nociception and pain in awake mice.bioRxiv : the preprint server for biology · 2023Article
- Noradrenergic Input from Nucleus of the Solitary Tract Regulates Parabrachial Activity in Mice.eNeuro · 2023Article
- The parabrachial to central amygdala circuit is a key mediator of injury-induced pain sensitization.bioRxiv : the preprint server for biology · 2023Article
- Differential activation of spinal and parabrachial glial cells in a neuropathic pain model.Frontiers in cellular neuroscience · 2023Article
- Brain nuclei and neural circuits in neuropathic pain and brain modulation mechanisms of acupuncture: a review on animal-based experimental research.Frontiers in neuroscience · 2023Review
- A nigro-subthalamo-parabrachial pathway modulates pain-like behaviors.Nature communications · 2022Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
The parabrachial (PB) complex mediates both ascending nociceptive signaling and descending pain modulatory information in the affective/emotional pain pathway. We hypothesized that PB hyperactivity influences chronic pain behavior after trigeminal nerve injury in rats. Following induction of neuropathic pain using the chronic constriction injury of the infraorbital nerve (CCI-ION) model, rats displayed spontaneous markers of pain and mechanical hyperalgesia extending beyond the receptive field of the injured nerve. PB neurons recorded from rats with CCI-ION displayed amplified activity, manifesting as significantly longer responses to sensory stimuli, compared to shams. These findings suggest that chronic neuropathic pain involves PB hyperactivity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.