ReviewHeliyon2018
An introduction to the maximum entropy approach and its application to inference problems in biology.
Review in Heliyon, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed.
- MERGE-RNA: a physics-based model to predict RNA secondary structure ensembles with chemical probing.Nucleic acids research · 2026Article
- Discovering interpretable low-dimensional dynamics using maximum entropy.Physical review. E · 2026Article
- Article
- Minimum-Entropy Optimal Control of Electromechanical Linkages for Energy Harvesting.Entropy (Basel, Switzerland) · 2026Article
- Optimization and comparison research on adaptive modularization BERT-SPAN model for named entity recognition of SARS-CoV-2 virus proteins.Scientific reports · 2026Article
- Beyond the Second Law: Darwinian Evolution as a Tendency for Entropy Production to Increase.Entropy (Basel, Switzerland) · 2025Article
- Umbrella Refinement of Ensembles-An Alternative View of Ensemble Optimization.Molecules (Basel, Switzerland) · 2025Article
- Hidden high-risk states identification from routine urban traffic.PNAS nexus · 2025Article
- Dynamic metabolic regulation of histone modifications during the yeast metabolic cycle.PloS one · 2025Article
- Computational Approaches to Predict Protein-Protein Interactions in Crowded Cellular Environments.Chemical reviews · 2024Review
- Multi-scale habitat modeling framework for predicting the potential distribution of sheep gastrointestinal nematodes across Iran's three distinct climatic zones: a MaxEnt machine-learning algorithm.Scientific reports · 2024Article
- Article
- Conserved and divergent signals in 5' splice site sequences across fungi, metazoa and plants.PLoS computational biology · 2023Article
- Self-similarity and the maximum entropy principle in the genetic code.Theory in biosciences = Theorie in den Biowissenschaften · 2023Article
- The Entropy of Entropy: Are We Talking about the Same Thing?Entropy (Basel, Switzerland) · 2023Review
- Generating synthetic multidimensional molecular time series data for machine learning: considerations.Frontiers in systems biology · 2023Article
- Modelling speciation: Problems and implications.In silico biology · 2023Article
- Inference of metabolic fluxes in nutrient-limited continuous cultures: A Maximum Entropy approach with the minimum information.iScience · 2022Article
- Maximum Entropy Technique and Regularization Functional for Determining the Pharmacokinetic Parameters in DCE-MRI.Journal of digital imaging · 2022Article
- Estimation of the probability risks of African swine fever outbreaks using the maximum entropy method in North Sumatra Province, Indonesia.Veterinary world · 2022Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A cornerstone of statistical inference, the maximum entropy framework is being increasingly applied to construct descriptive and predictive models of biological systems, especially complex biological networks, from large experimental data sets. Both its broad applicability and the success it obtained in different contexts hinge upon its conceptual simplicity and mathematical soundness. Here we try to concisely review the basic elements of the maximum entropy principle, starting from the notion of 'entropy', and describe its usefulness for the analysis of biological systems. As examples, we focus specifically on the problem of reconstructing gene interaction networks from expression data and on recent work attempting to expand our system-level understanding of bacterial metabolism. Finally, we highlight some extensions and potential limitations of the maximum entropy approach, and point to more recent developments that are likely to play a key role in the upcoming challenges of extracting structures and information from increasingly rich, high-throughput biological data.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.