ArticleItch (Philadelphia, Pa.)2017
Topography of itch: evidence of distinct coding for pruriception in the trigeminal nerve.
Article in Itch (Philadelphia, Pa.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 22 citations in OpenAlex.
- Efficacy of Concentrated Heat for Treatment of Insect Bites: A Real-world Study.Acta dermato-venereologica · 2023Trial
- Association of Skin Dryness and Disease-related Parameters with Mechanical Alloknesis in Atopic Dermatitis: A Crosssectional and Prospective Cohort Study.Acta dermato-venereologica · 2026Article
- Experimental acute muscle pain and itch induce similar inhibitory effects on corticospinal excitability.Pain reports · 2025Article
- Induction and generalization of nocebo effects on itch.Experimental dermatology · 2022Article
- Attentional Bias Modification Training for Itch: A Proof-of-Principle Study in Healthy Individuals.Frontiers in medicine · 2021Article
- New insights into the mechanisms behind mechanical itch.Experimental dermatology · 2020Article
- Flare Size but Not Intensity Reflects Histamine-Induced Itch.Skin pharmacology and physiology · 2020Article
- Modulation of Itch by Localized Skin Warming and Cooling.Acta dermato-venereologica · 2018Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionLittle is known about the topographical distribution of pruriception (in particular for nonhistaminergic itch), although conditions with chronic itch frequently occur in distinct anatomic and often bilateral patterns. This study aimed to investigate regional differences in the sensitivity to itch stimuli by assessing the intensity of itch, pain, and cutaneous neurogenic flare evoked by histamine and cowhage in different anatomic regions in 20 healthy volunteers.
methodsItch was induced by 1% histamine applied with a prick lancet or by insertion of 25±5 cowhage spicules in 4 regions: volar/dorsal forearm, lower back, and chin. The duration and intensity of itch and pain following each pruritic stimulus were measured by a continuous visual analogue scale (VAS
resultsPeak itch intensity was lower at the chin (19.4±3.6) compared with other areas (mean of 3 locations; 41.3±4.4), independently of whether histamine or cowhage was applied ( DISCUSSION: In conclusion, sensitivity to histaminergic and non-histaminergic itch diverges considerably between body regions. Lower density of pruriceptive CMH and CMI-neurons or distinct neuronal substrates for itch in the mandibular part of the trigeminal area may explain the observed reduced itch and vasomotor responses.
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