ReviewBioMed research international2018
Histopathology in Periprosthetic Joint Infection: When Will the Morphomolecular Diagnosis Be a Reality?
Review in BioMed research international, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Best microbiological practice recommendations for the diagnosis of peri-prosthetic joint infections: the CRIOGO bacteriology reference center network.Annals of clinical microbiology and antimicrobials · 2025Pooled it
- Management of Periprosthetic Joint Infections: A Multidisciplinary Approach.Antibiotics (Basel, Switzerland) · 2026Review
- Diagnostic Accuracy of Synovial Alpha-Defensin and Histopathology for Periprosthetic Joint Infection: A Validation Study.Journal of orthopaedic case reports · 2026Article
- Evaluating chronic bone and soft tissue infections with [European journal of nuclear medicine and molecular imaging · 2026Article
- Diagnosing orthopaedic infection by identifying neutrophils in whole histology slide images with machine learning trained on publicly available datasets.Bone & joint research · 2026Article
- Periprosthetic joint infections in a city hospital in Türkiye: A cross-sectional study.Medicine · 2025Observational
- Prosthetic Knee Joint Infection with Haemophilus influenzae 1 Year After Total Knee Arthroplasty: A Case Report and Literature Review.The American journal of case reports · 2025Review
- The Ongoing Struggle to Find a Gold Standard for PJI Diagnosis.Reports (MDPI) · 2025Review
- Comparison of the Diagnostic Performance of Culture, Histopathology, and mNGS for Periprosthetic Joint Infection Using Periprosthetic Tissue Samples: A Prospective Clinical Study.Infection and drug resistance · 2025Article
- Diagnostics in Late Periprosthetic Infections-Challenges and Solutions.Antibiotics (Basel, Switzerland) · 2024Review
- A rare case of periprosthetic joint infection of the hip due to Kocuria spp.BMC geriatrics · 2023Article
- Understanding orthopedic infections through a different perspective: Microcalorimetry growth curves.Experimental and therapeutic medicine · 2022Article
- One-Stage Hip Revision Arthroplasty Using Megaprosthesis in Severe Bone Loss of The Proximal Femur Due to Radiological Diffuse Osteomyelitis.Tropical medicine and infectious disease · 2021Article
- Current Guideline for Diagnosis of Periprosthetic Joint Infection: A Review Article.Hip & pelvis · 2021Review
- The EBJIS definition of periprosthetic joint infection.The bone & joint journal · 2021Article
- Massive Osteolytic Lesion of the Femur after Total Knee Arthroplasty.Arthroplasty today · 2020Article
- Plasma Cell Infiltration on Histopathological Samples of Chronic Bone and Joint Infections due toJournal of bone and joint infection · 2020Article
- Fabrication of PLLA/CPolymers · 2019Article
- Intra-operative diagnosis of periprosthetic joint infection can rely on frozen sections in patients without synovial fluid analyses.International orthopaedics · 2019Article
- Correlation of histological and microbiological findings in septic and aseptic knee implant failure.Archives of orthopaedic and trauma surgery · 2019Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The presence of a polymorphonuclear neutrophil infiltrate in periprosthetic tissues has been shown to correlate closely with the diagnosis of septic implant failure. The histological criterion considered by the Musculoskeletal Infection Society to be diagnostic of periprosthetic joint infection is "greater than five neutrophils per high-power field in five high-power fields observed from histologic analysis of periprosthetic tissue at ×400 magnification." Surgeons and pathologists should be aware of the qualifications introduced by different authors during the last years in the histological techniques, samples for histological study, cutoffs used for the diagnosis of infection, and types of patients studied. Recently, immunohistochemistry and histochemistry studies have appeared which suggest that the cutoff point of five polymorphonuclear neutrophils in five high-power fields is too high for the diagnosis of many periprosthetic joint infections. Therefore, morphomolecular techniques could help in the future to achieve a more reliable histological diagnosis of periprosthetic joint infection.
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Registered trials
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