ArticleInternational journal of ophthalmology2018
Changes in intrinsic excitability of ganglion cells in degenerated retinas of RCS rats.
Article in International journal of ophthalmology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 8 citations in OpenAlex.
- Resting-state electroretinography reveals pathological retinal oscillations in retinitis pigmentosa mice and patients.Nature communications · 2026Article
- A novel GCaMP6f-RCS rat model for studying electrical stimulation in the degenerated retina.Frontiers in cell and developmental biology · 2024Article
- High-Fidelity Reproduction of Visual Signals by Electrical Stimulation in the Central Primate Retina.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Light-induced charge generation in polymeric nanoparticles restores vision in advanced-stage retinitis pigmentosa rats.Nature communications · 2022Article
- Morphological Factors that Underlie Neural Sensitivity to Stimulation in the Retina.Advanced nanobiomed research · 2021Article
- Reply to: Questions about the role of P3HT nanoparticles in retinal stimulation.Nature nanotechnology · 2021Article
- Computational challenges and opportunities for a bi-directional artificial retina.Journal of neural engineering · 2020Article
- Retinal Ganglion Cell Death as a Late Remodeling Effect of Photoreceptor Degeneration.International journal of molecular sciences · 2019Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo evaluate the intrinsic excitability of retinal ganglion cells (RGCs) in degenerated retinas.
methodsThe intrinsic excitability of various morphologically defined RGC types using a combination of patch-clamp recording and the Lucifer yellow tracer in retinal whole-mount preparations harvested from Royal College of Surgeons (RCS) rats, a common retinitis pigmentosa (RP) model, in a relatively late stage of retinal degeneration (P90) were investigated. Several parameters of RGC morphologies and action potentials (APs) were measured and compared to those of non-dystrophic control rats, including dendritic stratification, dendritic field diameter, peak amplitude, half width, resting membrane potential, AP threshold, depolarization to threshold, and firing rates.
resultsCompared with non-dystrophic control RGCs, more depolarizations were required to reach the AP threshold in RCS RGCs with low spontaneous spike rates and in RCS OFF cells (especially A2o cells), and RCS RGCs maintained their dendritic morphologies, resting membrane potentials and capabilities to generate APs.
conclusionRGCs are relatively well preserved morphologically and functionally, and some cells are more susceptible to decreased excitability during retinal degeneration. These findings provide valuable considerations for optimizing RP therapeutic strategies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.