Evidence map›Paper›PMID 29861964›Full record

ArticleChemical science2015

Gold-catalyzed tandem reactions of amide-aldehyde-alkyne coupling and cyclization-synthesis of 2,4,5-trisubstituted oxazoles.

Pierre Querard, Simon A Girard, Nick Uhlig, Chao-Jun Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemical science, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Defluorinative Cyclization of Enamides with Fluoroalkyl Halides Through Two Vicinal C(spAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  2. Article
  3. Article
  4. Review
  5. Alkynyl Thioethers in Gold-Catalyzed Annulations To Form Oxazoles.Angewandte Chemie (International ed. in English) · 2017
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Pierre QuerardDepartment of Chemistry , FQRNT Center for Green Chemistry and Catalysis , McGill University , 801 Sherbrooke Street West , Montreal , Quebec H3A 0B8 , Canada . Email: cj.li@mcgill.ca.
Simon A GirardDepartment of Chemistry , FQRNT Center for Green Chemistry and Catalysis , McGill University , 801 Sherbrooke Street West , Montreal , Quebec H3A 0B8 , Canada . Email: cj.li@mcgill.ca.
Nick UhligDepartment of Chemistry , FQRNT Center for Green Chemistry and Catalysis , McGill University , 801 Sherbrooke Street West , Montreal , Quebec H3A 0B8 , Canada . Email: cj.li@mcgill.ca.
Chao-Jun LiDepartment of Chemistry , FQRNT Center for Green Chemistry and Catalysis , McGill University , 801 Sherbrooke Street West , Montreal , Quebec H3A 0B8 , Canada . Email: cj.li@mcgill.ca.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We report the first cationic gold(i)-catalyzed one-pot reaction of amide, alkyne and aldehyde followed by cyclization, to successfully access highly substituted oxazoles derivatives in good yields. A single catalyst allows the occurring of this multi-step reaction atom- and step-economically, with water as the only theoretical side product.

Identifiers

PMID29861964
PMCPMC5950834

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.